Healthy Subjects Clinical Trial
Official title:
Pulmonary Arterial Pressure Response During Exercise in COPD and Healthy Subjects
Background:
The extent of increase in systolic pulmonary arterial pressure (PAPs) during exercise in
patients with COPD is unpredictable from lung function data. The non-invasive assessment of
pulmonary hemodynamics during exercise and flow-mediated vasodilatation measurement may give
useful data in the rehabilitation of COPD patients.
Methods:
Patients with stable, severe COPD and healthy, age-matched subjects (H) perform semi supine
echocardiography with PAPs measurement. COPD patients perform ramp protocol with gas
exchange detection. Serum hsCRP level is also determined in COPD patients. Endothel
dysfunction is detected by flow mediated vasodilation measurement after arm strangulation
with Doppler ultrasonography.
Primary endpoint:
The degree of pulmonary artery systolic pressure change during exercise?
Secondary endpoint:
1. The degree of right ventricular function change during exercise?
2. Is endothel dysfunction manifested with pulmonary artery pressure rise?
3. What is the correlation between the systemic inflammatory marker hsCRP and the degree
of pulmonary artery pressure rise?
Background: The extent of increase in systolic pulmonary arterial pressure (PAPs) during
exercise in patients with COPD is unpredictable from lung function data. The non-invasive
assessment of pulmonary hemodynamics during exercise by semi-supine echocardiography and
flow-mediated vasodilatation measurement may give useful data in the rehabilitation of COPD
patients.
Methods: Patients with stable, severe COPD and healthy, age-matched subjects (H) perform
semi supine echocardiography with PAPs measurement. COPD patients perform ramp protocol with
gas exchange detection. Serum hsCRP level is also determined in COPD patients. All of the
subjects perform complete lung function with body pletysmography and diffusion capacity
measurement. Endothel dysfunction is detected by flow mediated vasodilation measurement
after arm strangulation with Doppler ultrasonography.
;
Observational Model: Cohort, Time Perspective: Cross-Sectional
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