Healthy Subjects Clinical Trial
Official title:
Novel Noninvasive Techniques to Study Neutrophil Airway Inflammation in an Ozone Challenge Model
The primary objective of this pilot study is to establish a model of neutrophil airway inflammation for future testing of anti-inflammatory substances in an early stage of clinical development. Moreover, the suitability of an electronic nose for early detection and diagnosis of airway inflammation will be determined.
Experimental ozone exposure of human subjects is known to induce transient neutrophilic
airway inflammation with sputum neutrophilia and elevated concentrations of inflammatory
mediators in bronchoalveolar lavage and sputum supernatants. In this study, ozone at a
concentration of 250 ppb will be inhaled for three hours in an ozone challenge chamber.
In a recent study, ozone challenge has been discussed as a model for pulmonary diseases
dominated by neutrophilic inflammation such as COPD, providing the possibility to test new
anti-inflammatory substances in early stages of clinical development.
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Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Basic Science
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