Endothelial Dysfunction Induced by Postprandial Lipemia

Healthy Subjects Clinical Trial

Official title:

Endothelial Dysfunction Induced by Postprandial Lipemia: Complete Protection Afforded by High Intensity Aerobic Interval Exercise

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00660491
• Other study ID #: Exercise, Food and Endothelium
• Status: Completed
• Phase: Phase 2
• First received: April 15, 2008
• Last updated: January 5, 2012
• Start date: January 2008
• Est. completion date: October 2008

Study information

• Verified date: January 2012
• Source: Norwegian University of Science and Technology
• Contact: n/a
• Is FDA regulated: No
• Health authority: Norway:National Committee for Medical and Health Research Ethics
• Study type: Interventional

Clinical Trial Summary

Postprandial lipemia and exercise oppose each other in terms of cardiovascular risk, however the mechanism of their interaction is not well understood.

Therefore we want to study vascular function, as assessed by brachial artery (BA) flow mediated dilation (FMD), in healthy men before and after a high fat meal (HFM) preceded (16-18 hrs) by rest, a single bout of continuous moderate intensity exercise (CME), and high intensity interval exercise (HIIE).

Recruitment information / eligibility

• Status: Completed
• Enrollment: 8
• Est. completion date: October 2008
• Est. primary completion date: September 2008
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 20 Years to 40 Years

Eligibility

Inclusion Criteria:

• male, 20-40years, BMI between 25 and 30, resident in Trondheim.

Exclusion Criteria:

• unstable angina, CHD, heart failure,

Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver), Primary Purpose: Treatment

Related Conditions & MeSH terms

• Healthy Subjects

Intervention

Other:
• exercise training
moderate intensity exercise group, and high intensity exercise group

Locations

Country	Name	City	State
Norway	NTNU	Trondheim

Sponsors (1)

Lead Sponsor	Collaborator
Norwegian University of Science and Technology

Country where clinical trial is conducted

Norway, 

References & Publications (1)

Tyldum GA, Schjerve IE, Tjønna AE, Kirkeby-Garstad I, Stølen TO, Richardson RS, Wisløff U. Endothelial dysfunction induced by post-prandial lipemia: complete protection afforded by high-intensity aerobic interval exercise. J Am Coll Cardiol. 2009 Jan 13;5 — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Flow mediated dilatation		baseline, post exercise, 30min, 2hour, 4hour post exercise	No
Secondary	blood lipid profile		same as flow mediated dilatation	No