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Healthy Subjects clinical trials

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NCT ID: NCT05072535 Completed - Healthy Subjects Clinical Trials

A Study to Evaluate Relative Bioavailability and Food-Effect of HA121-28 Tablet B in Healthy Subjects

Start date: October 8, 2021
Phase: Phase 1
Study type: Interventional

The study will be divided into 2 parts. The first part is a relative bioavailability study of HA121-28 tablet A and HA121-28 tablet B, and the second part is a food effect study of HA121-28 tablet B. Both Parts are single-dose, randomized, open-label, two-period crossover study to evaluate relative bioavailability HA121-28 tablet B in healthy subjects and the effect of food on pharmacokinetic profile of HA121-28 tablet B, respectively.

NCT ID: NCT05070195 Completed - Healthy Subjects Clinical Trials

A Study to Investigate the Drug-drug Interactions (DDIs) Between SKLB1028 and Midazolam in Healthy Subjects

Start date: June 7, 2021
Phase: Phase 1
Study type: Interventional

This is a single-center, open-label phase I clinical study to investigate the effect of SKLB1028 on the pharmacokinetics of Midazolam and its metabolite 1'-OH-midazolam in healthy subjects. This study also aims to evaluate the safety and tolerability of SKLB1028 in the presence of Midazolam.

NCT ID: NCT05045313 Completed - Healthy Subjects Clinical Trials

A Study to Evaluate the Drug-drug Interactions (DDIs) of DBPR108 With Warfarin Sodium, Digoxin, Probenecid in Healthy Subjects

Start date: October 20, 2021
Phase: Phase 1
Study type: Interventional

This is a three-part, single-center, open-label phase I clinical study to characterize the DDIs potential of DBPR108 with Warfarin sodium, Digoxin, or Probenecid in healthy subjects. This study also aims to evaluate the safety and tolerability of DBPR108 in the presence of Warfarin sodium, Digoxin, or Probenecid.

NCT ID: NCT05031624 Completed - Healthy Subjects Clinical Trials

A Phase 1 Study of Subcutaneous CDX-0159 in Healthy Subjects

Start date: August 30, 2021
Phase: Phase 1
Study type: Interventional

This is a study to determine the safety and pharmacokinetics of CDX-0159 administered subcutaneously in healthy subjects.

NCT ID: NCT05023031 Completed - Healthy Subjects Clinical Trials

Evaluation of Pharmacokinetic and Safety of NVP-2102 and NVP-2102-R in Healthy Subjects

Start date: October 5, 2021
Phase: Phase 1
Study type: Interventional

The purpose of this study is to compare the pharmacokinetics and safety of NVP-2102 and NVP-2102-R.

NCT ID: NCT05021666 Completed - Healthy Subjects Clinical Trials

A Phase 1, Double-blind, Randomized, Placebo-controlled, Single- and Multiple-dose Escalating Study

Start date: July 29, 2020
Phase: Phase 1
Study type: Interventional

This will be a randomized, double-blind, placebo-controlled, single- and multiple SC dose escalating study conducted in 2 parts.

NCT ID: NCT05014490 Completed - Healthy Subjects Clinical Trials

Bioequivalence Study of Test and Reference 120 mg Etoricoxib Film-coated Tablets in Healthy Volunteers

Start date: February 24, 2021
Phase: Phase 1
Study type: Interventional

The present study is a comparative bioavailability study performed to assess bioequivalence between a Test medication (Exib 120 mg etoricoxib film-coated tablets manufactured by PrJSC "Pharmaceutical firm "Darnitsa" [Ukraine]) and a Reference medication (marketed medicinal product Arcoxia® 120 mg etoricoxib film-coated tablets, Marketing Authorisation Holder: UAB "Merck Sharp&Dohme", Lithuania) in healthy volunteers.

NCT ID: NCT04993404 Completed - Healthy Subjects Clinical Trials

Pharmacokinetics Of Jaktinib In Subjects With Hepatic Impairment And Normal Hepatic Function

Start date: August 27, 2021
Phase: Phase 1
Study type: Interventional

This multi-center, open-label, parallel-controlled, single-dose Phase 1 study is being conducted to directly characterize the pharmacokinetic (PK) profiles and safety of Jaktinib following administration of a single oral dose in subjects with varying degrees of hepatic impairment compared to healthy matched control subjects with normal hepatic function(matched by age, weight, and sex).

NCT ID: NCT04983732 Completed - Healthy Subjects Clinical Trials

A Bioavailability Study of FL-101 in Healthy Male and Female Subjects

Start date: September 11, 2021
Phase: Phase 1
Study type: Interventional

This will be a single-center, randomized, open-label, single dose, parallel study to assess the absolute bioavailability of FL-101 when administered via the subcutaneous (SC) and intravenous (IV) routes.

NCT ID: NCT04951505 Completed - Healthy Subjects Clinical Trials

Safety and Intrapulmonary Pharmacokinetics of Cefepime and Taniborbactam in Healthy Subjects

Start date: June 29, 2021
Phase: Phase 1
Study type: Interventional

This is a single-center, open-label study to assess the safety and intrapulmonary pharmacokinetics of cefepime and taniborbactam in healthy adult male and female subjects. Thirty subjects will receive a total of 6 doses of cefepime-taniborbactam (2 g cefepime/0.5g taniborbactam) administered intravenously every 8 hours. Following the sixth dose of cefepime-taniborbactam, subjects will be assigned to one of six bronchoscopy sampling times.