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Clinical Trial Details — Status: Withdrawn

Administrative data

NCT number NCT00159302
Other study ID # RES11115
Secondary ID
Status Withdrawn
Phase
First received
Last updated
Start date September 2003
Est. completion date September 2006

Study information

Verified date July 2019
Source Imperial College London
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

This pilot study will measure the baseline levels and the intra- and inter-subject variability of exhaled (alveolar and bronchial) and nasal NO in smoking subjects with mild and moderate COPD on or off steroid treatment, smoking healthy volunteers and non-smoking mild asthmatics off steroids, using multiple exhalation flow rates.

I


Description:

n addition, exploratory markers of iNOS activity (eg. 3-nitrotyrosine, nitrite, nitrate and 3-nitro-4-hydoxyphenylacetic acid) in blood, sputum, urine and exhaled breath condensate will be evaluated. We will also evaluate exhaled and nasal NO in a population of mild asthmatics in order to obtain baseline and variability data for future clinical studies involving asthmatic subjects.


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Study Design


Intervention

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Locations

Country Name City State
United Kingdom Section of Airway Disease, Asthma Lab, Imperial College London, Royal Brompton Hospital London

Sponsors (2)

Lead Sponsor Collaborator
Imperial College London GlaxoSmithKline

Country where clinical trial is conducted

United Kingdom, 

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