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Healthy Skin clinical trials

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NCT ID: NCT06440473 Recruiting - Healthy Skin Clinical Trials

Visualization of Topical Zoryve vs. Vehicle Using Line Field Optical Coherence Tomography in Healthy Skin

Start date: May 28, 2024
Phase: Phase 4
Study type: Interventional

The goal of this study is to visualize the deposition of topical 0.3% roflumilast (Zoryve) compared to vehicle using Line-Field Optical Coherence Tomography (LC-OCT) in vivo in healthy skin. We hypothesize that the application of topical 0.3% roflumilast (Zoryve) will result in distinct patterns of deposition within the epidermal and dermal layers compared to the vehicle. Specifically, we anticipate observing deeper penetration and more uniform distribution of roflumilast within the skin layers, indicative of enhanced efficacy, as visualized by LC-OCT imaging.

NCT ID: NCT04406454 Completed - Nevus Clinical Trials

The Application of Non-invasive and Cellular Level Resolution Fullfield Optical Coherence Tomography: Establishment and Analysis of Subcutaneous Cellular Level Image Database of Anatomical Locations in Healthy Volunteers and Evaluation of Usability

Start date: July 6, 2020
Phase:
Study type: Observational

ApolloVue® S100 Image System is a medical device class II. The objective of this protocol is to image skin of healthy volunteers and to evaluate the performance of full-field optical coherence tomography (FF-OCT) device - the ApolloVue® S100 Image System in imaging skin microstructures of healthy skin at different anatomical locations and nevi for different skin types and different age and to evaluate usability of the ApolloVue® S100 Image System.

NCT ID: NCT03625167 Completed - Healthy Skin Clinical Trials

Effect of a Basic Skin Care Product on the Structural Strength of the Skin

Start date: July 31, 2018
Phase: N/A
Study type: Interventional

The main aim of this study is to investigate in a suction blister model, whether the use of a basic skin care formulation increases the mechanical integrity/adhesion of the dermo-epidermal junction.

NCT ID: NCT01951391 Completed - Healthy Skin Clinical Trials

Effect of Surfactants on the Skin Microbiome

Start date: September 2013
Phase: N/A
Study type: Interventional

Up to 10 volunteers will be recruited to evaluate the microbial environment on their forearms. Following informed consent, bacterial swabs will be obtained at baseline from the forearms of all subjects. Their forearms will then be washed with one of the study cleansers. Subjects will then have their forearms swabbed for bacteria at the following time points: 10 minutes, 6 hours, and 24 hours after the wash. DNA will be extracted from all swabs and bacterial diversity evaluated by 16S pyrosequencing.

NCT ID: NCT01552135 Completed - Healthy Skin Clinical Trials

Pilot Study - Putative Penetration of Nanoparticles in Sunscreen in Intact or Sunburned Skin

Start date: January 2012
Phase:
Study type: Observational

The investigators want to study if nanoparticles of titaniumdioxide are penetrating skin when the skin is intact and when the skin is sunburned. The hypothesis is "Does nanotitandioxide penetrate intact or sunburned skin?"

NCT ID: NCT00971282 Completed - Healthy Skin Clinical Trials

Adjunctive Usage of a Moisturizing Lotion (Cetaphil® Moisturizing Lotion) to Limit the Skin Irritation Linked to the Set-Up of a Treatment by Topical Retinoid (Differin® Gel 0,1%) in Healthy Subjects of Chinese Origins

Start date: December 2008
Phase: Phase 4
Study type: Interventional

This is a single-center study, randomized, Investigator/Evaluator-blinded bilateral (split-face) comparison. The objective: To assess the benefit of the concomitant use of a Moisturizing Lotion in reducing the skin irritation induced by a adapalen gel treatment in Chinese Subjects.

NCT ID: NCT00111254 Completed - Skin Wrinkling Clinical Trials

The Effects of Microdermabrasion on Skin Remodeling

Start date: June 2002
Phase: N/A
Study type: Interventional

This research project aims to study the effects of microdermabrasion, a technique causing minimal injury used to improve the appearance of fine lines, wrinkles, and scars. Subjects will undergo microdermabrasion, which is a gentle "sand-blasting" of the skin. We are interested in determining how this procedure works at rebuilding the skin following microdermabrasion.