Creatine Supplementation on Kidney Function in Resistance-trained Individuals

Healthy Persons Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01817673
• Other study ID #: Creatine & kidney
• Status: Completed
• Phase: N/A
• First received: March 20, 2013
• Last updated: March 22, 2013
• Start date: July 2011
• Est. completion date: February 2013

Study information

• Verified date: March 2013
• Source: University of Sao Paulo
• Contact: n/a
• Is FDA regulated: No
• Health authority: Brazil: National Committee of Ethics in Research
• Study type: Interventional

Clinical Trial Summary

There is a claim that creatine supplementation might affect kidney function, especially in those consuming a high-protein diet. The aim of this study was to investigate the effects of creatine supplementation on kidney function in resistance-trained individuals ingesting a high-protein diet.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 46
• Est. completion date: February 2013
• Est. primary completion date: February 2013
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 30 Years

Eligibility

Inclusion Criteria:

• participation in recreational resistance training

• consumption of a high-protein diet (= 1.2 g/Kg/d)

Exclusion Criteria:

• vegetarian diet

• use of creatine supplements in the past 6 months

• chronic kidney disease

• use of anabolic steroids.

Study Design

Allocation: Randomized, Endpoint Classification: Safety Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator)

Related Conditions & MeSH terms

• Healthy Persons

Intervention

Dietary Supplement:
• creatine
20 g/d for 5 d followed by 5 g/d throughout the trial
• placebo

Locations

Country	Name	City	State
Brazil	Univsersity of Sao Paulo	Sao Paulo

Sponsors (1)

Lead Sponsor	Collaborator
University of Sao Paulo

Country where clinical trial is conducted

Brazil, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	kidney function	as assessed by 51Cr-EDTA clearance	3 months	Yes
Secondary	proteinuria		3 months	Yes
Secondary	albuminuria		3 months	Yes
Secondary	serum urea		3 months	Yes
Secondary	serum creatinine		3 months	Yes