Visuo-Vestibular Adaptation in Virtual Reality

Healthy Person Clinical Trial

— VIVRA  

Official title:

Visuo-Vestibular Adaptation in Virtual Reality

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT06213792
• Other study ID #: 69HCL23_1326
• Status: Completed
• Start date: April 4, 2024
• Est. completion date: May 2, 2024

Study information

• Verified date: April 2024
• Source: Hospices Civils de Lyon
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The vestibulo-ocular reflex (VOR) stabilizes the gaze during rapid head movements by inducing an eye rotation of equivalent amplitude but in the opposite direction to the head rotation. Normally, the ratio of eye rotation amplitude to head rotation, or VOR gain, is 1. Under some conditions such as growth or the use of corrective glasses, this gain is adapted to the new visuo-vestibular conditions. This well-known sensorimotor adaptation phenomenon can be achieved through the experimental creation of a conflict between vestibular and visual information.

Incremental velocity error (IVE) allows for a rapid adaption of the VOR at high speed by synchronously projecting a laser target that moves to create a progressively increasing visuo-vestibular conflict. However, this method does not correspond to the ecological conditions of VOR use, as the training is conducted in darkness and the visuo-vestibular conflict does not involve the entire visual scene.

Recreating this type of adaptation in a virtual reality environment could allow for adaptation with a visual stimulus involving the entire visual scene, thus more closely resembling the physiological conditions of VOR use. We hypothesize that a visual simulation of the entire scene would be more effective than an isolated target in VOR adaptation during high velocity head rotation.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 18
• Est. completion date: May 2, 2024
• Est. primary completion date: May 2, 2024
• Gender: All
• Age group: 18 Years to 60 Years

Eligibility

Inclusion Criteria:

• Age from 18 to 60

• Understanding of the experimental instructions

• Informed Consent

Exclusion Criteria:

• Underlying ENT or neurological disorders

• Corrected Visual Acuity lower than 5/10

• Other conditions leading to oscillopsia or ataxia

• Oculomotor palsy, ocular instability in primary position

• Treatment that may affect ocular motility (psychotropes)

• Cervical rachis pathology with instability

• Cochlear Implants

• Non-stabilized medical disease

• Subject suffering from debilitating motion sickness or Virtual Reality sickness

• Pregnant women

• Patients under tutelage

• Patient without social security

Related Conditions & MeSH terms

• Healthy Person

Intervention

Other:
• Adaptation of the VOR
Subjects will undergo adaptation of their VOR in virtual reality in two different conditions. The side on which the adaptation will take place and the type of condition with which the patients will start will be randomized. Subject will undergo passive rapid head movements done by an experienced examinator whilst fixing a target in front of them. The movement of the target relative to the movement of the head will increase every 90 seconds by 10% until the movement of the visual scene is twice that of the head movement. In one condition the visual scene will be only a target in a grey void. In the other condition the visual scene will be more complex and represent a target in the room in which the subject is seated. Subjects will undergo both conditions at least 7 days apart.

Locations

Country	Name	City	State
France	Hôpital Neurologique	Bron

Sponsors (1)

Lead Sponsor	Collaborator
Hospices Civils de Lyon

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	VOR gain	VOR gain corresponds to the amplitude of the eye rotation devided by the amplitude of the head rotation for a given head impulse.	7 days