Healthy Participants Clinical Trial
Official title:
Ultrasound Effects on Human Motor Cortical Plasticity
The purpose of this study is to test the duration and effect of single element focused ultrasound to the primary motor cortex on healthy human participants with the use of transcranial focused ultrasound and transcranial magnetic stimulation.
Previous research has shown ultrasound to inhibit motor cortical excitability though it is
currently not known how long these effects last. This is an important consideration if
ultrasound is to be translated and advanced to clinical or therapeutic uses as this study
will help to determine suitable ultrasound durations for efficacious use. The investigators
will test the duration of ultrasound neuromodulation using transcranial magnetic stimulation
which will elicit a recordable and quantifiable metric of motor cortical excitability in the
form of a motor evoked potential.
Participants will complete 3 study visits. During the first study visit, participants will
complete Magnetic Resonance Imaging and Computed Tomography scans for TUMS localization in
visits 2 and 3. Each participant will undergo motor cortex thresholding prior to their study
TUMS stimulation procedure. Depending on randomization, subjects may receive one or two TUMS
stimulation procedures at each session.
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