Healthy Participants Clinical Trial
Official title:
Understanding the Lung Microbiome in HIV-Infected & HIV-Uninfected Individuals
In its original phase, this cohort study recruited subjects who were either HIV-positive or
HIV-negative healthy controls, to analyze the community structure of the lung microbiome.
Original recruitment was planned to occur both at the University of Michigan Medical Center
and clinics, and at VA Ann Arbor Healthcare System.
Enrollment for the original cohort is completed, and all current activity of this project is
occurring at VA Ann Arbor, where both Veteran subjects and non-Veteran subjects are eligible
to participate. This study is currently recruiting only healthy HIV-negative subjects.
Participation, described below, involves a research bronchoscopy procedure.
This is a non-interventional cohort study with single time point cross-sectional comparisons and longitudinal analyses, with the primary study aims of: evaluating how the immune deficiency associated with HIV infection influences the lung microbiome and lung function, and evaluating changes in lung microbiota over time. The study also aims to characterize the microbiome of the lower respiratory tract, determine the relationship between the lower respiratory Microbiome and the upper respiratory and gastrointestinal tract microbiomes, evaluate the influence of smoking on the microbiome compared with the influence of smoking on pulmonary function and respiratory systems, and to evaluate how Pneumocystis infection influences HIV-infected and HIV-uninfected individuals. ;
Observational Model: Case-Only, Time Perspective: Prospective
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