Pharmacokinetic Analysis of Nicotinamide Riboside

Healthy Participants Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02300740
• Other study ID #: 45141
• Status: Completed
• Phase: Phase 0
• First received: November 20, 2014
• Last updated: February 26, 2015
• Start date: December 2014

Study information

• Verified date: November 2014
• Source: Aarhus University Hospital
• Contact: n/a
• Is FDA regulated: No
• Health authority: Denmark: The National Committee on Health Research Ethics
• Study type: Interventional

Clinical Trial Summary

Nicotinamide riboside is a newly discovered vitamin B3. The pharmacokinetics in humans is so far not analyzed.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 12
• Est. primary completion date: February 2015
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 30 Years

Eligibility

Inclusion Criteria:

• BMI 18-25, healthy, male,

Exclusion Criteria:

• liver or kidney diseases, other diseases

Study Design

Allocation: Randomized, Endpoint Classification: Pharmacokinetics Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Healthy Participants

Intervention

Dietary Supplement:
• Nicotinamide riboside
NIAGEN, ChromaDex

Locations

Country	Name	City	State
Denmark	Medical Research Laboratories, Aarhus University Hospital	Aarhus

Sponsors (2)

Lead Sponsor	Collaborator
Aarhus University Hospital	University of Copenhagen

Country where clinical trial is conducted

Denmark, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Serum nicotinamide riboside		8 hours, blood samples every 15 min	No
Secondary	serum concentrations of metabolites of nicotinamide riboside		8 hour, blood samples every 15 min	No
Secondary	area under the curve for serum nicotinamide riboside		8 hours, blood samples every 15 min	No
Secondary	calculation of halftime of serum nicotinamide riboside		8 hours, blood samples every 15 min	No
Secondary	calculation of C-max of serum nicotinamide riboside		8 hours, blood samples every 15 min	No
Secondary	calculation of t-max of serum nicotinamide riboside		8 hours, blood samples every 15 min	No