Restoring Molecular Circadian Rhythm

Status Suspended

Clinical Trial Summary

The goal is to address the mechanisms that account for alteration of circadian rhythms with age. As the blood of aged individuals can produce this alteration, the investigators propose to use such blood samples to "age" circadian rhythms in cultured cells. The investigators will verify aged blood-dependent alteration of rhythms and then conduct molecular screens to reverse this decline. If the investigators identify specific genes that can restore molecular circadian rhythm in vitro, the investigators will explore these in animal models (Drosophila, mouse).

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04086589
Study type	Observational
Source	University of Pennsylvania
Contact
Status	Suspended
Phase
Start date	August 19, 2019
Completion date	December 17, 2024

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