Effects of Muscle Strengthening and Fatigue on Activities in Cortex and Muscle

Healthy Adults Clinical Trial

— YM110099E  

Official title:

Effects of Cross Education Training on Corticocortical and Corticomuscular Functional Connectivity

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT06333756
• Other study ID #: YM110099E
• Status: Completed
• Phase: N/A
• Start date: May 1, 2021
• Est. completion date: August 1, 2022

Study information

• Verified date: December 2022
• Source: National Yang Ming University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

We will explored the effect of cross education training on different cortex functional connectivity, cortex and muscle functional connectivity, and maximal voluntary contraction.

Healthy participants receive cross education training of the elbow flexor (12 rep./set, 3sets, 60%MVC, 180°/s, eccentric).Maximal voluntary contraction, electroencephalogram and electromyogram will record during cross education tasks to determine the effects of cross education training on cortical network and muscle functional connectivity

Description:

Cross education (CE) training was observed in 1894, when unilateral strength training of single limb was found to increase in strength of untrained muscle group. CE has potential clinical relevance in rehabilitation for patient who have acute injuries of the limb, post-surgical limb immobilization and certain neurological disorders with unilateral muscle weakness. Although CE has several potential clinical application, the precise physiological mechanisms underlying CE remains unknown. Previous studies reported that CE may involve bilateral cortical activity in both contralateral primary motor cortex (cM1), and ipsilateral primary motor cortex (iM1).In addition, neuroimaging studies have demonstrated that bilateral supplementary motor area, but CE immediate change of functional connectivity in cortical network remains unknown.

The purposes of this study are to investigate the immediate effect of CE training of biceps brachii (1) Immediate change of functional connectivity in cortical network; (2) Immediate change of functional connectivity in cortex and target muscle; (3) Explore immediate change of corticomuscular functional connectivity on maximal voluntary contraction. We hypothesize that (1) Bilateral cortical motor network that exhibit changes in functional connectivity during cross education; (2) Cross education would immediately enhance functional connectivity between cortex and target muscle; (3) Cross education would immediately change corticomuscular functional connectivity on maximal isometric voluntary contraction.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 40
• Est. completion date: August 1, 2022
• Est. primary completion date: April 30, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 20 Years to 40 Years

Eligibility

Inclusion Criteria:

1. Healthy adults who are 20-40 years old

Exclusion Criteria:

1. Upper extremity (UE) pain or discomfort

2. Medical condition that substantially influenced their UE strength

3. Experience of UE surgery

4. Paresthesia in UE

5. Open wound on UE

Related Conditions & MeSH terms

• Healthy Adults

Intervention

Other:
• Cross education
Cross education training of the biceps brachii (12 rep./set, 3sets, 60%MVIC,180°/s, eccentric contraction)

Locations

Country	Name	City	State
Taiwan	National Yang-Ming University	Taipei

Sponsors (1)

Lead Sponsor	Collaborator
National Yang Ming University

Country where clinical trial is conducted

Taiwan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Corticocortical coherence	Level of electroencephalography and electromyography synchronization in frequency domain when participants maintain 20% maximal voluntary contraction	Measured immediately after cross education training
Primary	Corticomuscular coherence	Level of electroencephalography and electromyography synchronization in frequency domain when participants maintain 20% maximal voluntary contraction	Measured immediately after cross education training
Primary	Maximal voluntary contraction	The ability to generate maximal voluntary elbow flexor force	Measured immediately after cross education training