Sensory Study: Taste and Tongue Biology

Healthy Adults Clinical Trial

— SweetTaste  

Official title:

Sensory Study: Taste and Tongue Biology

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05985928
• Other study ID #: 2587
• Secondary ID: R21DC018906
• Status: Completed
• Start date: March 20, 2023
• Est. completion date: May 20, 2023

Study information

• Verified date: May 2023
• Source: University of Massachusetts, Amherst
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Researchers will investigate the correlation between a) self-reported dietary intake of foods and beverages, b) intensity of sucrose stimuli, and c) liking rating of sweet stimuli, with the relative expression of the taste receptor genes from human fungiform papillae (TAS1R2 and TAS1R3). * This research will provide new information on how sweet taste perception is regulated. - The hypothesis: Greater dietary consumption of sugar and sweet foods is associated with reduced expression of the sweet taste receptors. - The results of this study could help to identify pathways to help modify sweet taste perception by uncovering this mechanism. Participants will sample solutions prepared with sweet ingredients, provide salivary DNA, and collect fungiform papillae. This will allow researchers and investigators to compare the relationship between the sweetness of stimuli, genetic differences in sweet taste receptors, and expression levels of sweet taste receptor genes.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 121
• Est. completion date: May 20, 2023
• Est. primary completion date: May 20, 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 45 Years

Eligibility

Inclusion Criteria:

1. between 18 and 45 years old,

2. have no tongue or cheek piercings,

3. not a user of tobacco products or electronic cigarettes (within the last year),

4. no known defects in taste or smell,

5. not pregnant or breastfeeding,

6. no history of chronic pain in the mouth,

7. not taking any prescription pain medication,

8. not taking any blood thinners,

9. no history of cancer or cancer treatment,

10. not diabetic or restricting intake of sugars for medical reasons, under the direction of a physician or healthcare provider

11. willing to undergo the Fungiform Papillae biopsy procedure

12. willing to provide salivary DNA

13. Not currently experiencing any COVID-19 symptoms

14. Not recently diagnosed (in the last 30 days) with COVID-19

15. No history of high blood pressure Exclusion Criteria: -

Related Conditions & MeSH terms

• Healthy Adults

Locations

Country	Name	City	State
United States	University of Massachusetts	Amherst	Massachusetts

Sponsors (2)

Lead Sponsor	Collaborator
University of Massachusetts, Amherst	National Institute on Deafness and Other Communication Disorders (NIDCD)

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Gene expression and sweet taste perception	The relative level of gene expression of sweet taste receptors (TAS1R2 and TAS1R3) and relationship with sweet taste perception (gLMS ratings of sampled sucrose)	Day 1 (single time-point)
Primary	Gene expression and sweet taste liking	The relative level of gene expression of sweet taste receptors (TAS1R2 and TAS1R3) and relationship with sweet taste perception (hedonic ratings of sampled sucrose)	Day 1 (single time-point)
Primary	Gene expression and dietary intake	The relative gene level expression of sweet taste receptors and relationship with self-reported dietary intake of sweet foods and beverages	Day 1 (single time-point)
Primary	Gene expression and sweet liker status	The relative gene level expression of sweet taste receptors and relationship with the self-reported liking of a variety of sweet foods and beverages	Day 1 (single time-point)
Secondary	Genetics and sweet taste perception	Genetic variability in sweet taste receptor genes and the relationship with perception of sweet stimuli (gLMS intensity ratings)	Day 1 (single time-point)
Secondary	Genetics and sweet taste liking	Genetic variability in sweet taste receptor genes and the relationship with hedonic ratings of sweet stimuli (hedonic ratings)	Day 1 (single time-point)
Secondary	Genetics and sweet liker status	Genetic variability in sweet taste receptor genes and the relationship with the self-reported liking of sweet-tasting foods and beverages	Day 1 (single time-point)