Acute Effects of Sitting and Physical Activity on Brain Health

Healthy Adults Clinical Trial

Official title:

Acute Effects of Sitting and Physical Activity on Cerebrovascular Circulation Among Adults

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04137211
• Other study ID #: Dnr:2019-00998
• Status: Completed
• Phase: N/A
• Start date: May 13, 2019
• Est. completion date: March 13, 2020

Study information

• Verified date: December 2022
• Source: The Swedish School of Sport and Health Sciences
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The specific aim of this study is to understand how a working day composed of prolonged sitting, sitting regularly interrupted by light aerobic exercise or resistance exercise affects an important mechanism underpinning healthy brain functions, namely cerebral blood flow. It is primarily focused on investigating these effects in ecologically valid conditions, i.e. activity patterns that closely resemble a typical day at the office.

Description:

The study will be a controlled crossover experimental trial with three conditions involving 13 adult participants aged between 40 and 60 years. Each participant will complete each of the three experimental conditions, separated by a washout period of minimum four days. As well, physical activity behaviours and sleep the day/night before the test day will be measured. The first visit will be a familiarization session. On the second, third, and fourth visits, participants will undergo three different standardized 3-hour interventions in a randomized order. Before and immediately after the three-hour interventions, blood pressure, augmentation index, and cerebral hemodynamic response of the prefrontal cortex during standardized cognitive tasks (1,2, and 3-back tests) will be measured. Additionally, saliva samples will be collected the morning of the test day and before and after the interventions, blood glucose will be assessed continuously during the trial, and fitness will be measured at the familiarization visit.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 13
• Est. completion date: March 13, 2020
• Est. primary completion date: March 13, 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 40 Years to 60 Years

Eligibility

Inclusion Criteria:

• Has a BMI under 35kg/m2

Exclusion Criteria:

• Has diabetes, epilepsy, or circulatory conditions

• Has experienced heart failure, stroke, or myocardial infarction

• Takes treatment for high blood pressure, sleep disorders, depression, or psychosis

Related Conditions & MeSH terms

• Healthy Adults

Intervention

Behavioral:
• Prolonged sitting with social break
Participants are required to sit for three hours (reading is permitted), with a toilet break in between. Every thirty minutes participants will have a short social break. Test day begins at 7:30 with pretest measures, followed by the intervention at about 9:00, which will end around 12:00, with subsequent posttest measures.
• Prolonged sitting with walk break
Participants are required to sit for three hours (reading is permitted), with a toilet break in between. Every thirty minutes participants will have a physical activity break, where they will perform a brisk walk for about three minutes on a treadmill at a predetermined speed and grade based on the fitness test performed during the familiarization session. Test day begins at 7:30 with pretest measures, followed by the intervention at about 9:00, which will end around 12:00, with subsequent posttest measures.
• Prolonged sitting with simple resistance activities
Participants are required to sit for three hours (reading is permitted), with a toilet break in between. Every thirty minutes participants will have a physical activity break, where they will perform simple resistance activities following a video for about three minutes. Test day begins at 7:30 with pretest measures, followed by the intervention at about 9:00, which will end around 12:00, with subsequent posttest measures.

Locations

Country	Name	City	State
Sweden	The Swedish School of Sport and Health Sciences (GIH)	Stockholm

Sponsors (7)

Lead Sponsor	Collaborator
The Swedish School of Sport and Health Sciences	ICA-gruppen, Intrum AB, Itrim, Monark Exercise, SATS, The Knowledge Foundation

Country where clinical trial is conducted

Sweden, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Changes in cerebral blood flow	Oxygenated and deoxygenated hemoglobin concentration changes measured with functional near-infrared spectroscopy	before to after 3 hour intervention
Secondary	Augmentation index	as a measure of arterial stiffness	before to after 3 hour intervention
Secondary	Blood glucose levels		during the 3 hour intervention
Secondary	Cortisol		before to after 3 hour intervention
Secondary	Mood	measured with the Positive and Negative Affect Schedule (PANAS) comprised of 20 affect states (10 positive and 10 negative), each affect state scored on a scale going from 1 (very slightly or not at all) to 5 (extremely)	before to after 3 hour intervention
Secondary	Sleepiness	measured with Karolinska Sleepiness Questionnaire; goes from 1 (extremely alert) to 9 (extremely sleepy)	before to after 3 hour intervention
Secondary	Cognitive performance	nback cognitive test (time and accuracy)	before to after 3 hour intervention
Secondary	Alertness	measured with a Visual Analogue Scale (VAS)	before to after 3 hour intervention