Healthy Adults Clinical Trial
Official title:
The INTER-CARDIO Study: The Impact of Commonly Consumed Fat on Cardiovascular
The purpose of this study is to investigate whether there are differences in postprandial cardiometabolic metabolic indices following interesterified fats used commercially versus application appropriate non- interesterifed alternative fat.
Aim: The current study aims to investigate the acute effects of commercially available
interesterified fat versus versus application appropriate non- interesterifed alternative fat
on 8 h postprandial cardiometabolic outcomes.
Hypothesis: Interesterified fat will induce a different cardiomtabolic response compared to a
non interesterifed, application appropriate fat.
Subjects: Participants will include 40 healthy male and female volunteers aged between the
ages of 35 and 75 years (since during this age metabolic changes start to take place).
Power calculation: Based on previous studies carried out by our group at King's College
London, a sample size of 20 participants (males and females separately) will allow a 2.16%
(percentage unit) difference in FMD to be detected (90% power, 0.05 alpha, SD 2.9. 50
participants will be recruited allowing for a 20% dropout rate.
Expected value:The study will provide novel information on the acute effects of commercially
relevant processed fats on postprandial lipaemia.
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