Study of SON-1010 (IL12-FHAB) in Healthy Adults

Status Completed

Clinical Trial Summary

SB102 is a randomized, double-blind, single center, placebo-controlled study in healthy adults starting with sentinel participants at each dose level to carefully assess the safety, tolerability, PK, and PD of SON-1010.

Clinical Trial Description

This is a study of SON-1010, a single-chain human Interleukin-12 (IL12) cytokine linked to a single-chain variable region (scFv) antibody fragment, known as the fully human albumin binding domain (FHAB). The albumin binding domain moiety of SON-1010 attaches to albumin in the bloodstream, resulting in significantly enhanced drug PK properties, potentially lower risk than IL12 alone, and a broader therapeutic index. Healthy volunteers will be assessed with single ascending doses of SON-1010. The design comprises up to 5 separate dosing cohorts, with a total of 8 participants (minimum of 7) in each cohort randomized to receive either SON-1010 (6 participants) or placebo (2 participants), for up to 40 participants. ;

Study Design

Related Conditions & MeSH terms

Healthy Adult

Clinical Trial Details

NCT number	NCT05408572
Study type	Interventional
Source	Sonnet BioTherapeutics
Contact
Status	Completed
Phase	Early Phase 1
Start date	July 27, 2022
Completion date	May 17, 2023

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