Non- Essential Amino Acid Requirements and Metabolism in Humans

Healthy Adult Males Clinical Trial

Official title:

Application of Indicator Amino Acid Oxidation Technique to Determine Non-essential Amino Acids/Nitrogen Requirements in Adult Humans

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02009917
• Other study ID #: H12-01683
• Status: Completed
• Phase: N/A
• First received: December 9, 2013
• Last updated: July 13, 2017
• Start date: October 2013
• Est. completion date: April 2015

Study information

• Verified date: July 2017
• Source: University of British Columbia
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Protein is a major structural component of all cells in the body. The nutritional importance of protein is because of their amino acids. 9 are called essential and 11 are called non-essential, based on whether we need to get them from diet. This classification is based on studies done using older techniques. Recent studies suggest that these so called non-essential amino acids play important roles in our body's health. For the first time, this proposal defines an experimental design to examine non- essential amino acid/nitrogen requirements and metabolism in humans using the Indicator Amino Acid Oxidation (IAAO) technique.

The objective of the current study is to examine the application of IAAO technique to determine the non-essential amino acid/nitrogen requirement in adult humans.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 6
• Est. completion date: April 2015
• Est. primary completion date: January 2015
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 20 Years to 40 Years

Eligibility

Inclusion Criteria:

• 20-40 years of age

• Male

• Classified as normal body weight based on body mass index (BMI) 18.5-25kg/m2

• Free of any concurrent illness

Exclusion Criteria:

• Men not in good health or have a metabolic, neurological, genetic or immune disorder including diabetes and hypertension

• Men who are classified as underweight(<18.5kg/m2), overweight(25-30kg/m2) or obese (>30kg/m2) using the BMI classification)

• Men who are allergic to milk, eggs and egg protein

Related Conditions & MeSH terms

• Healthy Adult Males

Locations

Country	Name	City	State
Canada	Child and Family Research Institute	Vancouver	British Columbia

Sponsors (2)

Lead Sponsor	Collaborator
University of British Columbia	Ajinomoto Co., Inc.

Country where clinical trial is conducted

Canada, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	13 Carbon dioxide production	Urine and breath samples will be collected to measure the rate of oxidation of expired breath and flux by enrichment of urine.	8 hours (1study day)