Health Status Clinical Trial
Official title:
Effect of Mediterranean Diets Based on Organic and Conventional Foods on Health Related Physiological Parameters in Urine and Blood/Plasma
Verified date | August 2017 |
Source | Newcastle University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Results from a small number of human cohort studies are also available and indicate that
there are positive associations between organic food consumption and reduced risk/incidence
of certain acute diseases (e.g. pre-eclampsia, hypospadias) and obesity/overweight.
Results from animal dietary intervention studies suggest that (i) switching to organic food
consumption results in significant changes in hormonal balances and an increase in immune
system responsiveness and (ii) differences in pesticide residue, cadmium, protein and
antioxidant concentrations between organic and conventional foods are major drivers for
hormonal balances and immune system parameters in animals.
However, there is virtually no published data from (i) long-term cohort studies focusing on
chronic diseases (e.g. cardiovascular disease, diabetes, cancer and neurodegenerative
conditions) and (ii) controlled human dietary intervention studies comparing effects of
organic and conventional diets. It is therefore currently not possible to assess whether and
estimate to what extent organic food consumption may affect human health.
Status | Enrolling by invitation |
Enrollment | 27 |
Est. completion date | December 31, 2017 |
Est. primary completion date | August 1, 2017 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 40 Years |
Eligibility |
Inclusion Criteria: Healthy adults No medications No known illness Exclusion Criteria: Any known illness Using prescribed medication Using over the counter vitamin or mineral supplements Allergy to any food |
Country | Name | City | State |
---|---|---|---|
Greece | Levidopa Field Station | Sivas | Sivas Festos |
United Kingdom | NU-Food Research Facility | Newcastle upon Tyne | Tyne and Wear |
Lead Sponsor | Collaborator |
---|---|
Newcastle University | The Sheepdrove Trust |
Greece, United Kingdom,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | IL-6 in Plasma measured using ELISA | Change from baseline 2 weeks post supplementation and 4 weeks post supplementation | ||
Primary | IL-6 in WBC measured using ELISA | Change from baseline 2 weeks post supplementation and 4 weeks post supplementation | ||
Primary | DNA damage in WBC measured using Western Blot | Change from baseline 2 weeks post supplementation and 4 weeks post supplementation | ||
Primary | Total antioxidant activity in plasma measured using PENTRA | Change from baseline 2 weeks post supplementation and 4 weeks post supplementation | ||
Primary | Phenols in plasma measured using GCMS | Change from baseline 2 weeks post supplementation and 4 weeks post supplementation | ||
Primary | Carotenoids in plasma measured using GCMS | Change from baseline 2 weeks post supplementation and 4 weeks post supplementation | ||
Primary | Pesticides in urine and plasma measured using ICPMS | Change from baseline 2 weeks post supplementation and 4 weeks post supplementation | ||
Primary | Isoprostanes in urine measured using ICPMS | Change from baseline 2 weeks post supplementation and 4 weeks post supplementation | ||
Primary | toxic metals in urine and plasma (Cd, Pb, Hg, Al) measured using ICPMS | Change from baseline 2 weeks post supplementation and 4 weeks post supplementation | ||
Primary | minerals in plasma (including Cu, Fe, Mn, Mg, Ca, I, Se) measured using ICPMS | Change from baseline 2 weeks post supplementation and 4 weeks post supplementation |
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