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Effect of Sumatriptan on Levcromakalim-Induced Symptoms in Individuals With Migraine — SLIM  

Headache Clinical Trial

Official title:
Effect of Sumatriptan on Levcromakalim-Induced Symptoms in Individuals With Migraine: A Randomized Double-Blind Two-Way Crossover Study

Clinical Trial Summary

The study aims to explore the effects of Sumatriptan on Levcromakalim-induced migraine in individuals with migraine without aura.

Clinical Trial Description

Opening of adenosine triphosphate-sensitive potassium (KATP) channels using Levcromakalim cause migraine attacks with and without aura in a high proportion of patients. Sumatriptan has been shown to reverse Levcromakalim-induced dilation of the middle meningeal artery and headache in healthy volunteers, indicating that Sumatriptan can overturn the physiological effects of levcromakalim. The study aims to explore the effects of Sumatriptan on Levcromakalim-induced migraine in individuals with migraine without aura. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05211050
Study type Interventional
Source Danish Headache Center
Contact Messoud Ashina, Prof.
Phone +45 38 63 33 85
Email messoud.ashina@regionh.dk
Status Recruiting
Phase N/A
Start date February 15, 2022
Completion date January 1, 2025
View Details
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