Efficacy of Percutaneous SPG Block in Aneurysmal SAH

Status Completed

Clinical Trial Summary

Researchers are trying to develop alternative means to help patients with headache pain secondary to aneurysmal subarachnoid hemorrhage (bleeding about the brain).

Clinical Trial Description

This study is an open label, feasibility study that will consist of fifteen patients. This study will enroll only patients who have aneurysmal SAH that are secured by endovascular coiling. When a patient notes a severe headache which requires medical intervention on at least day 3 of the hospital admission, they will be asked if they would like to participate in an open label trial to use a bilateral SSPGB in addition to traditional medical management per unit protocol. The risks and benefits of the procedure will be explained to the patient. The patient will then either agree or disagree. If the patient disagrees, they will not be enrolled in the study. If the patient agrees, they will sign an informed consent and will be enrolled. Inclusion and exclusion criteria will be reviewed before enrolling a patient. The patients will first rate their pain from 0-10 on the numeric rating scale (NRS) (10 being the most severe). If their pain is at a level 5 or more and it is not responsive to traditional medical therapies, they will be a candidate for the study. The patients will receive bilateral injections as outlined below (5 mL: 4.5mL of 0.5% bupivacaine and 0.5mL of 10mg/mL dexamethasone on each side for total volume of 10 mL). Thirty minutes later and 24 hours following injection, the patient will rate their pain from 0-10 on the NRS. The description of the procedure is stated below. A success would be considered a drop in their pain score of at least 2. Adverse effects will also be recorded 30 minutes after the procedure and the following day. Chart review on both provider and nursing notes will be performed on subsequent days to evaluate for adverse effects. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04331938
Study type	Interventional
Source	Mayo Clinic
Contact
Status	Completed
Phase	Phase 1
Start date	November 1, 2020
Completion date	April 8, 2024

View Details

See also
Status	Clinical Trial	Phase
Withdrawn	`NCT03472872` - A Comparative Efficacy Trial of IV Acetaminophen Versus IV Ketorolac for Emergency Department Treatment of Generalized Headache	Phase 4
Withdrawn	`NCT05410366` - Safe Harbors in Emergency Medicine, Specific Aim 3
Withdrawn	`NCT02866084` - Neuromodulation Treatment of Vestibular Migraines	N/A
Active, not recruiting	`NCT03537573` - Provider-Targeted Behavioral Interventions to Prevent Unsafe Opioid Prescribing for Acute Pain in Primary Care	N/A
Recruiting	`NCT05891808` - miR-155 Expression in Episodic and Chronic Migraine
Not yet recruiting	`NCT04352218` - Safety Profile of PETALO CVS in the Treatment of Non-thrombotic Internal Jugular Vein Stenosis and Chronic Headache	Phase 2
Completed	`NCT02734992` - Acceptance and Commitment Therapy vs Medical Treatment as Usual Wait-list Control for Primary Headache Sufferers	N/A
Completed	`NCT01327118` - Prostaglandin F2alpha in a Human Headache Model	N/A
Completed	`NCT01153789` - Study of Oculomotor Dysfunction Leading to Children Vertigo	N/A
Not yet recruiting	`NCT00969995` - Identification of Inflammatory Markers in Migraine Patients	N/A
Not yet recruiting	`NCT00752921` - Randomized Placebo Controlled Trial With Etoricoxib That is Taken to Prevent the Yom Kippur Headache	Phase 4
Terminated	`NCT00291395` - PGI2 Induced Headache and Cerebral Haemodynamics in Healthy Volunteers	Phase 1
Completed	`NCT00212810` - Evaluation of the Effectiveness of Topiramate in Preventing the Transformation From Episodic Migraine to Chronic Daily Headache.	Phase 4
Completed	`NCT00263094` - An End to the Yom Kippur (and Ramadan) Headache	N/A
Completed	`NCT00135122` - Prednisolone in the Treatment of Withdrawal Headache in Probable Medication Overuse Headache	Phase 3
Completed	`NCT02475005` - An Intervention to Improve Adolescent Headache Self-management	N/A
Completed	`NCT03163901` - The Effect of OMT on Functional Outcomes and Anti-inflammatory Biomarkers in Mild to Moderate Traumatic Brain Injury	N/A
Completed	`NCT01664585` - Exercise Training With Physically Active Lifestyle to Reduce Headache and Quality of Life	N/A
Completed	`NCT04632420` - Evaluation of Headache and Childbirth in a Chronic Pain Population
Recruiting	`NCT05033613` - Home Blood Pressure Monitoring Before and After COVID-19 Vaccination in Patients at High Risk of Cardiovascular Disease