Headache Clinical Trial
Official title:
S100B Protein Measures in the Care of Non-traumatic Headaches in the Emergency Department
The main objective of this pilot study is to make a first assessment of the discriminating
ability of a dosage of S100B protein for differential diagnosis between primary headaches and
secondary headaches.
For this, the investigators will compare serum S100B protein between two groups of headache
patients presenting at the emergency department: 1 group of primary headache patients and 1
group of secondary headache patients.
If the difference between the two groups proves potentially discriminating, the investigators
will seek to determine the discriminating ability of the S100B protein by calculating the
area under the ROC curve.
The reference diagnostic will be set at one month across the entire clinical picture and
imaging by an expert committee composed of a neurologist, a radiologist and an emergency
physician.
The secondary objectives of this study are:
A. To seek an association between S100B protein levels and the onset of pain depending on
whether it is more or less than 3 hours.
B. To assess the association between S100B protein levels and mortality at day 28.
C. To evaluate the association between S100B protein levels and hospital care: average length
of stay in the emergency department, lumbar puncture, brain imaging, average length of
hospital stay.
D. To evaluate the prognostic value of determination of S100B protein on the occurrence of a
secondary headache at 1 month.
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