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NCT00357864 Clinical Trial

Carbachol´s Headache Inducing Characteristics and Effects on the Cerebral Blood Flow

Headache Clinical Trial

Official title:
Basic Research on Carbachol´s Headache Inducing Characteristics and Effects on the Cerebral Blood Flow in a Humane Experimental Headache Model

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00357864
Other study ID # 2006-002462-19
Secondary ID
Status Completed
Phase N/A
First received July 26, 2006
Last updated August 29, 2007
Start date July 2006
Est. completion date April 2007

Study information
Verified date August 2007
Source Danish Headache Center
Contact n/a
Is FDA regulated No
Health authority Denmark: Danish Medicines Agency
Study type Observational

Clinical Trial Summary

To investigate headache score and accompanying symptoms during and after infusion of carbachol.

Description:

To investigate headache score and accompanying symptoms during and after infusion of carbachol.

Changes in regional cerebral blood flow (rCBF) in the area supplied by middle cerebral artery (MCA), blood flow in MCA, diameter of the superficial temporal artery (STA) and radial artery (RA)

Recruitment information / eligibility
Status Completed
Enrollment 15
Est. completion date April 2007
Est. primary completion date
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Both
Age group 18 Years to 40 Years
Eligibility Inclusion Criteria:

- Healthy volunteers

- Aged 18-40

- 50-100 kg

- Fertile women must use safe contraceptives (IUD, oral contraceptives, surgical sterilisation and long lasting gestagen.

Exclusion Criteria:

- Tension type headache more than once/month

- Other primary headaches

- Daily medication except contraceptives

- Drug taken within 4 times the halflife for the specific drug except contraceptives

- Pregnant or lactating women

- Exposure to radiation within the last year

- Headache within the last 24 hours before start of trial

- Hypertension

- Hypotension

- Respiratory or cardiac disease

Study Design

Primary Purpose: Screening, Time Perspective: Longitudinal

Related Conditions & MeSH terms

Intervention

Drug:
• carbachol

Locations
Country Name City State
Denmark Dansih Headache Center Glostrup

Sponsors (1)
Lead Sponsor Collaborator
Danish Headache Center

Country where clinical trial is conducted

Denmark, 

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