Medication-overuse Headache (MOH): Withdrawal or Use of Preventative Medications Directly?

Headache Clinical Trial

Official title: Medication-overuse Headache (MOH): Withdrawal or Use of Preventative Medications Directly? A Randomized Multi-centre Follow-up.

Status Completed

Clinical Trial Summary

It is a common belief that patients with MOH rarely respond of preventative medications whilst overusing acute medications. However, no randomized trial has been done previously to prove such statement. Based on some clinical experiences, our hypothesis are patients with probably MOH may benefit from use of preventive medications better than treatment with abrupt withdrawal or no specific treatment.

Clinical Trial Description

This randomized multi-centre study started January 2004, and patients with probably MOH have been included from five different University hospitals in Norway. The last patient was included November 9th 2006, final inclusion date was December 31th 2006. At this time a total of 64 patients with probable MOH according to the International Classification of Headache Disorders, 2nd Edition (2004) were included.

The included patients were randomized to one out of three possible options:

1. Abrupt withdrawal of the acute medication(s) they have been overusing. After 3 month:

use of preventative medication (best choice)in those who need such treatment, 12 month follow-up.

2. Start with preventative medication (best choice) directly without abrupt withdrawal, 12 month follow-up.

3. No specific treatment (controls), 5 month follow-up. ;

Related Conditions & MeSH terms

• Headache
• Headache Disorders, Secondary

• NCT number: NCT00159588
• Study type: Interventional
• Source: Norwegian University of Science and Technology
• Status: Completed
• Phase: N/A
• Start date: January 2004
• Completion date: December 2007