Headache, Migraine Clinical Trial
Official title:
Adolescents With Migraine: What's Stress Got To Do With It?
The overall objective of this proposal is to better define the relationship between perceived stress, hair cortisol, and migraine in adolescents. This will be done by creating 2 arms of the study: those with migraines (cases) and those without migraines or headaches (controls). Each arm will answer several of the same questionnaires and have hair cortisol samples taken multiple times over the course of 12 weeks.
The overall objective of this proposal is to better define the relationship between perceived
stress, hair cortisol, and migraine in adolescents. Although adolescents most frequently
report stress as their migraine trigger, stress measurement and treatment are usually beyond
the scope of routine clinical care. Hair cortisol levels may identify stressed adolescents
who need structured stress management, as well as provide objective evidence for the medical
community, migraineurs (i.e. individuals who experience migraines), and their families, who
may be reluctant to accept stress as a migraine factor. The rationale for this research is
that scientific validation of an association between stress and migraine will inform future
prevention studies in the headache field and potentially identify a stress biomarker for
migraine.
This prospective study will enroll 67 adolescents (aged 13-17) with migraine and 33
adolescents without migraine for 12 weeks with the following aims:
Aim 1: Measure the relationship between hair cortisol concentration and perceived stress in
adolescents with and without migraine.
Hypothesis: The association between hair cortisol and perceived stress (3 month averages)
will be a positive in both adolescents with and without migraine.
Aim 2: Measure the relationship between migraine frequency with perceived stress and hair
cortisol concentration in adolescents with migraine.
Hypothesis: The association between migraine frequency with (a) perceived stress and (b) hair
cortisol will be positive in adolescents with migraines.
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