Headache Disorders Clinical Trial
Official title:
The Effects of a Long-lasting Infusion of Vasoactive Intestinal Peptide (VIP) on Headache, Cranial Hemodynamic in Healthy Volunteers
Vasoactive intestinal peptide (VIP) is a peptide of 28 amino acid residues that belongs to the glucagon/secretin superfamily of peptides. It is produced in different regions of the nervous system, including the brain, trigeminovascular system and several autonomic nerves. Once released from neurons, it acts on vasoactive intestinal peptide receptor 1 (VPAC1), vasoactive intestinal peptide receptor 2 (VPAC2) and pituitary adenylate cyclase-activating polypeptide type I receptor (PAC1), by mediating smooth muscle relaxation, vasodilation and water secretion. Along with other neuropeptides, such as calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-activating polypeptide (PACAP), it is released from the trigeminal afferents and exerts a strong vasodilating activity on the cranial vasculature, sharing the activation of adenylate cyclase. Especially, it shares 70% structure with PACAP and acts on the same receptors. But, unlike it, VIP cannot induce a long-lasting vasodilation and has a modest capability to induce migraine attacks. Whether a long-lasting infusion of VIP may induce a prolonged vasodilation in the cerebral vessels and migraine, as a twenty-minute infusion of PACAP, is unknown.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Not yet recruiting |
NCT03632928 -
Day to Day Variation of Pressure Pain Threshold and Muscle Hardness
|
||
| Completed |
NCT00246350 -
Spinal Manipulation for Treatment of Chronic Headaches
|
Phase 2 | |
| Completed |
NCT05404113 -
Sustained Natural Apophyseal Glide and Deep Friction Massage in Patients With Cervicogenic Headache
|
N/A | |
| Recruiting |
NCT03416114 -
RegistRare: a Retro-prospective Registry of Rare Primary Headaches in Italian Tertiary Headache Centres
|
N/A | |
| Enrolling by invitation |
NCT04976985 -
Osteopathic Manipulative Treatment and Migraine Headaches
|
N/A | |
| Recruiting |
NCT05153876 -
An Open Internet-based Survey and Natural Language Processing Project Analysing Written Monologues by Headache Patients
|
||
| Recruiting |
NCT06041997 -
Smartphone Use Restriction as Treatment of Primary Headache
|
N/A | |
| Active, not recruiting |
NCT04936321 -
Intervention for Sleep and Pain in Youth: A Randomized Controlled Trial
|
N/A | |
| Completed |
NCT04220580 -
Multiomics After Cold Pressor Test of People Who Are Unable to Have Headache
|
N/A | |
| Completed |
NCT03385174 -
Carbon Monoxide Headache Triggering Properties as Well as Effects on the Brain's Vessels and Blood Flow
|
N/A | |
| Completed |
NCT03137147 -
Intervention for Sleep and Pain in Youth
|
N/A | |
| Completed |
NCT02910921 -
Individualized Prediction of Migraine Attacks Using a Mobile Phone App and Fitbit
|
||
| Recruiting |
NCT05619354 -
Validity and Reliability of the Dutch HDI
|
||
| Recruiting |
NCT06206772 -
Resting State Functional Connectivity in Cluster Headache
|
||
| Terminated |
NCT02624661 -
Glycerol Block of the Trigeminal Ganglion in Trigeminal Neuralgia Using a New Neuronavigation-based Surgical Technique
|
Phase 1/Phase 2 | |
| Completed |
NCT02662972 -
Botulinum Toxin Type A Block of the Sphenopalatine Ganglion in Trigeminal Neuralgia. Safety Issues.
|
Phase 1/Phase 2 | |
| Completed |
NCT05381012 -
Fibromyalgia Syndrome on Patients With Chronic Migraine
|
N/A | |
| Completed |
NCT04891848 -
Assessment of Inflammation in Primary Headaches
|
||
| Recruiting |
NCT04715685 -
Mind Body Balance for Pediatric Migraine
|
N/A | |
| Completed |
NCT00457496 -
Effectiveness of a Cognitive and Physical Intervention to Reduce Head and Muscle Pain in Working Communities
|
Phase 3 |