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Aprepitant for Nause and Vomiting Induced by Chemoradiotherapy in HNSCC

Vomiting Clinical Trial

Official title:
A Prospective, Open-label, Single-arm Study for Efficacy and Safety of Three-drug Antiemetic Regimen to Prevent the Emesis During Radiotherapy With Concurrent Chemoradiotherapy in Locally Advanced HNSCC

Clinical Trial Summary

To evaluate the safety and efficacy of aprepitant combined with ondansetron and dexamethasone to prevent nausea and vomiting induced by Intensity-modulated Radiotherapy (IMRT) cisplatin-chemotherapy regimen in locally advanced squamous cell carcinoma of head and neck

Clinical Trial Description

To evaluate the complete response rate, nause-free rate, vomiting-free rate, and the quality of life of aprepitant combined with ondansetron and dexamethasone for the nausea and vomiting induced by chemoradiotherapy in HNSCC. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03572829
Study type Interventional
Source Chinese Academy of Medical Sciences
Contact
Status Completed
Phase Phase 2
Start date March 1, 2018
Completion date July 1, 2020
View Details
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