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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT03053310
Other study ID # B049201629484
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date January 25, 2017
Est. completion date February 28, 2025

Study information

Verified date February 2022
Source AZ Sint-Jan AV
Contact Araceli Diez-Fraile, Phd
Phone 0032(0)50459660
Email araceli.diez-fraile@azsintjan.be
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Background Approximately half of head and neck cancer patients are 65 years or older at diagnosis. Treatment decisions in this older HNCA population are challenging, because of the lack of evidence-based guidelines. Surgery is often the treatment of choice in a HNCA setting where curative treatment is intended. Though chronological age per se has not been reported as a contraindication for surgery, data are limited and often the result of retrospective studies. Measurement of functional age, through a comprehensive geriatric assessment, has been suggested by several international cancer organizations to be a better prognostic indicator. At the divisions of maxillofacial surgery and otorhinolaryngology, a geriatric assessment is part of routine preoperative staging for patients of 70 years old or older. Objectives The investigators aim to determine the value of G8 to predict 30-day postoperative comorbidity in an older HNCA population undergoing elective curative surgery. Moreover, they aim to examine the vulnerability profile of patients undergoing elective head and neck surgery for an oncology diagnosis. Study design All patients of 70 years and older, presenting at the divisions of maxillofacial surgery and otorhinolaryngology for curative surgery of a solid head and neck tumour undergo a geriatric consult as part of routine preoperative staging. The presence of postoperative morbidity and mortality within the first 30 days after surgery will be collected as a primary endpoint. At 30±10 days postoperative, all patients will be re-evaluated with the G8 and the CGA. Patient' quality of life will also be re-examined within 30 days postoperative and again at 6 and 12 months postoperative. Conclusion There is still no consensus whether older HNCA patients should receive a different treatment compared to younger patients. Data related to the vulnerability profile of older patients requiring HN surgery, and the predictive value of geriatric screening for postoperative morbidity could enable better patient selection in the future.


Recruitment information / eligibility

Status Recruiting
Enrollment 94
Est. completion date February 28, 2025
Est. primary completion date February 28, 2024
Accepts healthy volunteers No
Gender All
Age group 70 Years and older
Eligibility Inclusion Criteria: - - Patients aged 70 years or older at time of enrolment - Both female and male patients - Patients that are Dutch or French-speaking - Patients with a histologically confirmed malignant tumour in the head and neck region, in specific oral cavity, larynx, and pharynx ('head and neck cancer', defined according to the NCCN guidelines) - Patients undergoing surgery for a solid head and neck cancer tumour under general anaesthesia. Preoperative data from patients considered ineligible for surgery, will also be registered for scientific purposes - Patients undergoing surgery and follow-up care at the division of maxillofacial surgery or Department of Otorhinolaryngology, Head and Neck Surgery Exclusion Criteria: - - Patients not eligible according to the abovementioned criteria - Patients with a spinocellular carcinoma of the skin - Patients with distant metastases (stage IVc) - Patients with another non-cured cancer, except for a squamous or basal cell carcinoma of the skin - Patients arriving at the emergency department for urgent surgical intervention - Patients diagnosed with severe dementia, according to the DSM IV or MMSE =18, or diagnosed psychiatric problems impeding proper preoperative assessment

Study Design


Related Conditions & MeSH terms


Locations

Country Name City State
Belgium AZ Sint-Jan Brugge-Oostende AV Bruges

Sponsors (1)

Lead Sponsor Collaborator
AZ Sint-Jan AV

Country where clinical trial is conducted

Belgium, 

Outcome

Type Measure Description Time frame Safety issue
Primary 30-day postoperative comorbidity 30 days postoperative
Secondary vulnerability percentage of patients undergoing HNCA surgery, based on geriatric consult at time of surgery
Secondary percentage of patients not considered eligible for HNCA surgery, based on geriatric consult and/or MOC consult prior to surgery, at time of multidisciplinary oncology consult
Secondary percentage of patients with major postoperative complications (grade >=3), Graded According to NCI CTCAE Version 4.0 30 days postoperative
Secondary quality of life, as measured with EORTC questionnaire 30 days, 6 months and 12 months postoperative
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