Head and Neck Cancers Clinical Trial
Official title:
Phase I Trial Evaluating the Safety of Durvalumab in Combination With Docetaxel, Cisplatin and 5-FU in Induction for Locally Advanced Head and Neck Squamous Cell Carcinoma
The prognosis of patients with locally advanced SCCHN is poor. Results of recent randomized
trials evaluating induction chemotherapy by docetaxel, cisplatin, 5 fluorouracil are
conflicting, and benefit on overall survival is uncertain. Improve efficacy of induction
chemotherapy is important without increase toxicities. Durvalumab is a promising agent in
SSCHN. The safety of combination of docetaxel, cisplatin, 5 fluorouracil with durvalumab is
unknown.
The aim of the study is to evaluate the feasibility and the safety of the association of DCF
(standard regimen for induction in SSCCHN) and durvalumab. The safety profile of DCF and
durvalumab are different, so the expected toxicities should not be additive. The addition of
durvalumab to DCF could improve the efficacy of induction chemotherapy and the prognostic of
patients with SSCCHN.
Concerning the translational research, the aim will be to explore the relationships between
immune capacity, specificity, activation state and clinical outcome to help elucidate the
determinants of response to immunotherapy.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Terminated |
NCT00721539 -
Assessing the da Vinci® Robotic Surgical System for Surgery of the Upper Aerodigestive Tract
|
N/A | |
| Recruiting |
NCT00568490 -
Identification of Secreted Markers for Tumor Hypoxia in Patients With Head and Neck or Lung Cancers
|
||
| Completed |
NCT01135849 -
B-Receptor Signaling in Cardiomyopathy
|
N/A | |
| Completed |
NCT00313027 -
Cervical Nodal Mets in Squamous Cell Carcinoma of H&N - MRI, FDG-PET, & Histopathologic Correlation
|
N/A | |
| Completed |
NCT00186433 -
A Longitudinal Study of Plasma EBV DNA in Nasopharyngeal Carcinoma From Both Endemic and Non-Endemic Patient Populations
|
N/A | |
| Completed |
NCT02854358 -
Efficacy of Traditional Persian Medicine Preparation Versus Artificial Saliva for Radiation Induced Xerostomia
|
Phase 2 | |
| Terminated |
NCT01114256 -
FNA Tumor Sampling for CD137 Modulation: A Pilot Study
|
N/A | |
| Terminated |
NCT00965003 -
MRI Laryngeal Imaging With a Surface Coil
|
Early Phase 1 | |
| Active, not recruiting |
NCT00490061 -
Phase II Lapatinib and Radiation for Stage III-IV Head and Neck Cancer Patients Who Cannot Tolerate Concurrent Chemotherapy
|
Phase 2 | |
| Recruiting |
NCT05122221 -
CRTE7A2-01 TCR-T Cell for HPV-16 Positive Advanced Cervical, Anal, or Head and Neck Cancers
|
Phase 1 | |
| Completed |
NCT02045368 -
Study of Insulin-like Growth Factor (IGF)-Methotrexate Conjugate in the Treatment of Advanced Tumors Expressing IGF-1R
|
Phase 1 | |
| Completed |
NCT01908504 -
Adaptive Pet Study
|
N/A | |
| Completed |
NCT05648682 -
Comparison of the Effectiveness of Three Different Gargates in Radiotherapy-Associated Oral Mucositis
|
N/A | |
| Not yet recruiting |
NCT03394417 -
StrataXRT vs Standard Clinical Practice for the Prevention of Acute Dermatitis in Head and Neck Cancers Patients
|
N/A | |
| Active, not recruiting |
NCT00580203 -
Collection Of Tissue, Blood, and Other Specimens From Patients With Head and Neck Tumors To Study the Causes, Diagnosis, Prevention and Treatment of Cancers
|
||
| Completed |
NCT00230295 -
Indirect Magnetic Resonance Lymphangiography of the Head and Neck Region Using Conventional Gadolinium-based Contrast
|
N/A | |
| Completed |
NCT00610415 -
Biopsy of Human Tumors for Cancer Stem Cell Characterization: a Feasibility Study
|
N/A | |
| Completed |
NCT01664936 -
Non-Invasive Cerenkov Luminescence Imaging of Lymphoma, Leukemia and Metastatic Lymph Nodes
|
||
| Completed |
NCT01163487 -
Metabolic Reprogramming Therapy for Treatment of Recurrent Head and Neck Cancers
|
Phase 1 | |
| Terminated |
NCT01137162 -
Clinical and Pathologic Studies of Patients Undergoing Treatment With EGFR Inhibitors
|
N/A |