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Hypofractionated Preoperative Radiation for Head and Neck Cancers (HyPR-HN)

Head and Neck Cancer Clinical Trial

Official title:
A Phase I Study of Hypofractionated Preoperative Radiation for Head and Neck Cancers (HyPR-HN)

Clinical Trial Summary

This is a phase 1 study to determine the safety of a condensed preoperative radiation regimen (10, 7, or 5 fractions) for the management of head and neck squamous cell carcinoma.

Clinical Trial Description

All subjects in this study will receive hypofractionated adjuvant radiation therapy, which will be subject to fractionation reduction, that being 10 fractions, 7 fractions, or 5 fractions, as compared to 30 fractions of conventional radiation therapy. The subjects will receive smaller number of fractions (total visits) but with a higher dose of radiation. Participants will receive a total radiation dose of 46 Gy in 10 fractions (Dose Level 1), 40 Gy in 7 fractions (Dose Level 2), or 35 Gy in 5 fractions (Dose Level 3), depending on the assigned experimental total fractions. Radiation will be delivered using intensity modulated radiation therapy (IMRT) with a daily cone-beam CT for five days a week, for less than two weeks depending on the assigned dose level at the time of enrollment. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05538533
Study type Interventional
Source Medical College of Wisconsin
Contact Medical College of Wisconsin Cancer Center Clinical Trials Offic
Phone 866-680-0505
Email cccto@mcw.edu
Status Recruiting
Phase N/A
Start date January 6, 2023
Completion date December 2026
View Details
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