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Ex VIvo DEtermiNed Cancer Therapy — EVIDENT  

Head and Neck Cancer Clinical Trial

Official title:
Ex Vivo Multi Drug Screening of Solid Tumours to Determine Personalised Therapy Efficacy and Resistance

Clinical Trial Summary

EVIDENT's aim is to test if ex vivo drug screening can predict whether patients with solid cancers will respond, or not respond, to standard care treatments. Patients undergoing standard care surgery to excise their tumour, those undergoing a biopsy, or those having a fluid aspirate of a solid tumour with surplus tissue available after diagnostic use will be eligible for this study. The specimen will then be assessed with ex vivo drug screening utilising all standard therapies and therapies that are more novel and in early stages of development. The results of the ex vivo drug screen will be compared to the cancer's actual response to standard care treatments for those that undergo therapy to determine how effective the test is at predicting treatment response.

Clinical Trial Description

The EVIDENT study is a feasibility / proof of concept study which is designed to determine if ex vivo screening of a patient's solid tumour can predict the effectiveness of standard cytotoxic chemotherapies and targeted inhibitors in solid cancers prior to the patients treatment. We aim to recruit 100 patient to each group starting with the six currently listed, but leave scope to add new groups of different solid cancers in the future. EVIDENT aims: - Demonstrate the feasibility of collecting fresh tumour samples within the NHS from patients with solid tumours for ex vivo screening - Demonstrate that tumour response to drug exposure can be measured and quantified within an ex vivo screening platform - Collect the participants' clinical outcome data (tumour response and progression free survival) to their standard of care treatment regimes and correlate with results from the ex vivo drug screen - Identify novel effective therapies - Investigate the tumour biopsies derived omics to determine the strength of well-established, less well-established biomarkers, and to identify novel biomarkers through correlation with the ex vivo drug screen results ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05231655
Study type Observational
Source Sheffield Teaching Hospitals NHS Foundation Trust
Contact Greg Wells, PhD
Phone +44 114 215 9098
Email g.wells@sheffield.ac.uk
Status Recruiting
Phase
Start date July 7, 2021
Completion date January 2027
View Details
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