Head and Neck Cancer Clinical Trial
Official title:
An Exploratory Study to Assess the Feasibility of Incorporating PET/MR in the Radiotherapy Pathway of Patients With Head and Neck Cancer and Guide Adaptive Dose Escalation
This is a pilot non-intervention study that aims to introduce PET/MRI, a state of the art new
imaging technique, into the radiotherapy treatment pathway of patients with head and neck
cancer. Ultimately the investigators aim to establish appropriate scanning and image
registration protocols, to allow progression to a randomized trial of adaptive radiotherapy
dose escalation. The latter is thought to potentially improve outcomes in this group.
Ten patients with squamous cell carcinoma (SCC) of the oropharynx, hypopharynx and larynx,
planned for radical treatment with radiotherapy (+/-chemotherapy), will be recruited. Study
participants will have two PET/MRI scans, with the radiotherapy immobilization devices in
situ. The first will be done prior to the start of radiotherapy, the second half way through
treatment.
Image quality will be assessed by comparing to standard diagnostic scans and different
registration methods will be compared to establish the best way of incorporating PET/MR image
data into the radiotherapy planning system. Patient tolerability and workflow considerations
will also be qualitatively assessed. Furthermore, a planning study will be conducted to
establish relevant treatment protocols for a subsequent dose escalation trial.
PET/MRI is an exciting new technology with a lot of potential in the context of adaptive
radiotherapy dose escalation. Within this pilot study the investigators aim to address the
technical challenges of using it in this context prior to proceeding to a randomized trial.
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