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Observational Study on Biomarkers in Head and Neck Cancer (HNprädBio) — HNprädBio  

Head and Neck Cancer Clinical Trial

Official title:
Observational Study on Biomarkers in Head and Neck Cancer

Clinical Trial Summary

The aim of this clinical research project is to validate the prognostic impact of potential biomarkers on loco-regional control of locally advanced head and neck cancer after definitive or adjuvant radiochemotherapy. The treatment is equal to the standard of care. Potential biomarkers from a previous retrospective study will be validated in this prospective study.

Clinical Trial Description

Objectives: Primary: Evaluation of local-regional recurrence- free survival after two years of patients with locally advanced head and neck cancer who received definitive or adjuvant radiochemotherapy. Secondary: Evaluation of disease-free -survival, metastases-free and overall survival after two years, of patients with locally advanced head and neck cancer. Outline: This is a multicenter observational study. The treatment is based on the center specific standard of care. The total dose will be between 69 and 73 Gy (definitive treatment) and 63 and 66 Gy (adjuvant treatment), the chemotherapy will be cisplatin- based. The aim of the analysis is to validate the prognostic impact of potential biomarkers on loco-regional control. This will lead to the definition of risk groups and stratification of patients and will help to individualize radiotherapy prescription in future trials. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02059668
Study type Observational
Source Technische Universität Dresden
Contact
Status Completed
Phase
Start date March 2014
Completion date June 2022
View Details
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