Head and Neck Cancer Clinical Trial
Official title:
Protein Expression Profiles in Oropharyngeal Squamous Cell Carcinoma
RATIONALE: Studying the proteins expressed in samples of tumor tissue from patients with
cancer may help doctors identify and learn more about biomarkers related to cancer. It may
also help doctors plan better treatment for patients with cancer of the oropharynx.
PURPOSE: This laboratory study is looking at protein expression in tumor tissue samples from
patients with cancer of the oropharynx.
OBJECTIVES:
- To investigate if some of the differences in gene expression are also reflected at the
protein level.
- To determine whether differences in gene expression that are also reflected at the
protein level can be used to develop markers for early detection and disease
surveillance.
- To identify targets for therapy.
OUTLINE: Archived tumor tissue samples are analyzed for expression of standard
immunohistological markers (e.g., p16, p53, and Ki-67) as well as expression of genes
identified in a previous gene expression study. Protein expression data are tested for
clinical and demographic correlates and compared with gene expression data.
;
Observational Model: Case-Only, Time Perspective: Retrospective
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