Head and Neck Cancer Clinical Trial
Official title:
Genetic Analysis of Head and Neck Squamous Cell Carcinoma
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help
doctors learn more about changes that occur in DNA and identify biomarkers related to
cancer.
PURPOSE: This laboratory study is looking at DNA in tissue samples from patients with head
and neck cancer.
OBJECTIVES:
- Assess common genetic mutations in tumor and germline DNA samples from patients with
head and neck squamous cell carcinoma (HNSCC).
- Search for viral DNAs and relate this information to demographics, tumor
characteristics, and patient prognosis.
- Search for novel viral sequences and cancer-associated gene mutations in young
nonsmoking HNSCC patients and in other distinct head and neck cancers.
- Determine tumor suppressor gene mutations in HNSCC patients and relate this information
to gene expression data.
- Validate gene expression information using independent techniques such as real-time PCR
on expressed sequences and immunohistochemistry.
OUTLINE: Genetic mutation analysis and gene expression studies are performed on tissue
samples from patients with head and neck squamous cell carcinoma. Techniques used include
real time-PCR and immunohistochemistry.
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Observational Model: Case-Only, Time Perspective: Prospective
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