Head and Neck Cancer Clinical Trial
Official title:
Proteomic Prediction of Clinical Benefit in HNSCC
Verified date | March 2013 |
Source | Vanderbilt-Ingram Cancer Center |
Contact | n/a |
Is FDA regulated | No |
Health authority | United States: Federal Government |
Study type | Observational |
RATIONALE: Studying samples of blood in the laboratory may help doctors learn more about
cancer. It may also help doctors predict how well patients will respond to treatment.
PURPOSE: This research study is looking at proteins in blood samples to predict treatment
benefit in patients with recurrent and/or metastatic squamous cell head and neck cancer.
Status | Completed |
Enrollment | 352 |
Est. completion date | December 2009 |
Est. primary completion date | December 2008 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | N/A and older |
Eligibility |
DISEASE CHARACTERISTICS: - Diagnosis of squamous cell head and neck cancer - Recurrent and/or metastatic disease - Meets 1 of the following criteria: - Previously treated with EGFR inhibitors and/or VEGF inhibitor on 1 of the following clinical trials, and has available blood samples: - A Phase I/II Study of Bevacizumab (rhu MAb VEGF) in Combination With OSI-774 for Patients With Recurrent or Metastatic Cancer of the Head and Neck - A Phase II Study of 250-mg ZD1839 Monotherapy in Recurrent or Metastatic or Both Recurrent and Metastatic Squamous Cell Carcinoma of the Head and Neck - Previously treated with cetuximab and has blood samples available from protocol VU-VICC-HN-0356 - Previously treated with conventional chemotherapy and has blood samples available from protocol VU-VICC-HN-0356 PATIENT CHARACTERISTICS: - Not specified PRIOR CONCURRENT THERAPY: - See Disease Characteristics |
Observational Model: Case-Only, Time Perspective: Retrospective
Country | Name | City | State |
---|---|---|---|
United States | Vanderbilt-Ingram Cancer Center | Nashville | Tennessee |
United States | Vanderbilt-Ingram Cancer Center - Cool Springs | Nashville | Tennessee |
United States | Vanderbilt-Ingram Cancer Center at Franklin | Nashville | Tennessee |
Lead Sponsor | Collaborator |
---|---|
Vanderbilt-Ingram Cancer Center | National Cancer Institute (NCI) |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Identification of patients who will benefit from treatment with EGFR and/or VEGF inhibitors based on serum proteomic profiles | upon analysis of each patient tissue collection | No |
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