Head and Neck Cancer Clinical Trial
Official title:
Re-irradiation and Stereotactic Cetuximab in Patients With Recurrent Carcinoma of the Head and Neck
Verified date | July 2009 |
Source | National Cancer Institute (NCI) |
Contact | n/a |
Is FDA regulated | No |
Health authority | United States: Federal Government |
Study type | Interventional |
RATIONALE: Monoclonal antibodies, such as cetuximab, can block tumor growth in different
ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and
help kill them or carry tumor-killing substances to them. Radiation therapy uses high-energy
x-rays to kill tumor cells. Stereotactic radiation therapy may be able to send x-rays
directly to the tumor and cause less damage to normal tissue. Giving cetuximab together with
stereotactic radiation therapy may kill more tumor cells.
PURPOSE: This phase II trial is studying how giving cetuximab together with stereotactic
radiation therapy works in treating patients with recurrent squamous cell carcinoma of the
head and neck cancer that cannot be removed by surgery.
Status | Completed |
Enrollment | 45 |
Est. completion date | |
Est. primary completion date | May 2011 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
DISEASE CHARACTERISTICS: - Histologically confirmed squamous cell carcinoma of the head and neck - Unresectable disease - Recurrent disease - No metastatic disease - Disease in previously irradiated area must be proven by biopsy or imaging - At least 3 months between prior radiotherapy and diagnosis of recurrent disease - Surgery or brachytherapy must be possible - Measurable or evaluable disease by RECIST criteria - No available curative therapy PATIENT CHARACTERISTICS: - Karnofsky performance status 60-100% - Not pregnant or nursing - No psychological, familial, social, or geographical reasons that would make monitoring the patient impossible - No other malignant disease PRIOR CONCURRENT THERAPY: - See Disease Characteristics - No concurrent participation in another clinical study of an experimental drug |
Allocation: Non-Randomized, Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
France | Centre Oscar Lambret | Lille |
Lead Sponsor | Collaborator |
---|---|
Centre Oscar Lambret |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Percentage of patients with nonprogressive disease at 12 months according to RECIST criteria | No |
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