Head and Neck Cancer Clinical Trial
Official title:
Phase II Trial of Irinotecan for Treatment of Metastatic Medullary Thyroid Cancer
RATIONALE: Drugs used in chemotherapy, such as irinotecan, work in different ways to stop the
growth of tumor cells, either by killing the cells or by stopping them from dividing.
PURPOSE: This phase II trial is studying how well irinotecan works in treating patients with
metastatic or inoperable thyroid cancer.
OBJECTIVES:
Primary
- Determine the response rate in patients with metastatic or inoperable locoregional
medullary thyroid cancer treated with irinotecan.
Secondary
- Determine the safety and tolerability of this drug in these patients.
OUTLINE: Patients receive irinotecan IV on days 1 and 8. Treatment repeats every 21 days for
4 courses in the absence of disease progression or unacceptable toxicity. Response is
assessed after completion of 4 courses. Patients achieving complete response (CR) or partial
response (PR) receive 2 additional courses beyond CR or PR. Patients who have stable disease
receive up to 12 total courses.
PROJECTED ACCRUAL: A total of 33 patients will be accrued for this study.
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