Head and Neck Cancer Clinical Trial
Official title:
Phase II Trial of Thalidomide for Therapy of Radioiodine-Unresponsive Papillary and Follicular Thyroid Carcinomas and Medullary Thyroid Carcinomas
RATIONALE: Thalidomide may stop the growth of thyroid cancer by stopping blood flow to the
tumor.
PURPOSE: Phase II trial to study the effectiveness thalidomide in treating patients who have
thyroid cancer.
OBJECTIVES:
- Determine the antitumor activity of thalidomide, in terms of tumor response and
duration of response, in patients with metastatic follicular, papillary, or medullary
thyroid carcinoma that is unresponsive to systemic radioiodine.
- Compare the differences in antitumor activity of this drug in patients with medullary
carcinomas vs those with papillary or follicular carcinomas.
- Determine the toxic effects and duration of toxic effects of this drug in these
patients.
OUTLINE: Patients receive oral thalidomide once daily for 2 weeks and then twice daily.
Treatment continues for 1 year in the absence of disease progression or unacceptable
toxicity.
PROJECTED ACCRUAL: A maximum of 50 patients will be accrued for this study.
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