Head and Neck Cancer Clinical Trial
Official title:
Phase II Study On Gemcitabine In Recurrent Or Metastatic Adenoid Cystic Carcinoma Of The Head And Neck
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing
so they stop growing or die.
PURPOSE: Phase II trial to study the effectiveness of gemcitabine in treating patients who
have recurrent or metastatic adenoid cystic cancer of the head and neck.
OBJECTIVES:
- Assess the therapeutic activity of gemcitabine, in terms of objective response and
duration of response, in patients with recurrent or metastatic adenoid cystic carcinoma
of the head and neck.
- Determine the acute toxicity of this drug in these patients.
OUTLINE: This is a multicenter study.
Patients receive gemcitabine IV over 30-60 minutes on days 1 and 8. Treatment repeats every
21 days for a maximum of 12 courses in the absence of disease progression or unacceptable
toxicity.
Patients are followed every 12 weeks until disease progression and then every 6 months
thereafter.
PROJECTED ACCRUAL: A total of 16-29 patients will be accrued for this study.
;
Primary Purpose: Treatment
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