HCV Related Cirrhosis Clinical Trial
Official title:
To Evaluate the Safety and Efficacy of Sofosbuvir and Ribavirin in Patients With HCV (Genotype 3) Related Decompensated Cirrhosis" - A Randomized Open- Label Study
In this prospective randomized trial, A Minimum of 300 consecutive patients of decompensated
HCV (Hepatitis C Virus) related cirrhosis, presenting to the Institute of Liver and Biliary
Sciences hospital will be included and those patients meeting the entry criteria received
treatment with 400 mg of Sofosbuvir, administered orally once daily, and Ribavirin
administered orally twice daily, with doses determined according to body weight(600 mg daily
in patients with a body weight of ≤60 kg,800 mg daily in patients weighing >60 and ≤80 kg,
and1000 mg daily in patients with a body weight of >80 kg). Based on the treatment duration,
patients would be randomized in either of the 3 treatment groups -
- Group 1 - Sofosbuvir + Ribavirin x 24 weeks
- Group 2 - Sofosbuvir + Ribavirin x 36 weeks
- Group 3 - Sofosbuvir + Ribavirin x 48 weeks
n/a