Salvage Living Donor Liver Transplantation for HCC Beyond All Criteria Yield Equivalent Results to Milan Criteria

Hcc Clinical Trial

Official title:

Salvage Living Donor Liver Transplantation for HCC Beyond All Criteria Yield Equivalent Results to Milan Criteria in High Prevalence Young HCC Patients Country.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04069416
• Other study ID #: 68954200
• Status: Completed
• Start date: January 2004
• Est. completion date: January 2019

Study information

• Verified date: August 2019
• Source: Ain Shams University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The present study aims to evaluate the impact of expanding criteria beyond Milan on tumor recurrence and patient survival that will help identify the best selection criteria for HCC transplanted patients.

Description:

Introduction:

HEPATOCELLULAR CARCINOMA (HCC) is the second leading cause of cancer mortality worldwide. Living donor liver transplantation (LDLT) for HCC patients has emerged as a rewarding therapy for a cure and a successful alternative where a Deceased donor liver transplantation (DDLT) program is lacking. Therefore, trials for careful expansion to Milan criteria have been adopted.

Aim of the study:

To evaluate the impact of expanding criteria beyond Milan on tumor recurrence and patient survival that will help identify the best selection criteria for HCC transplanted patients

Recruitment information / eligibility

• Status: Completed
• Enrollment: 241
• Est. completion date: January 2019
• Est. primary completion date: December 2015
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 70 Years

Eligibility

Inclusion Criteria:

• All patient transplanted for HCC eligible for transplant (no vascular invasion-no extra hepatic metastasis)

• age>18y

Exclusion Criteria:

• other etiology for liver transplant rather than HCC

• patient not fit for surgery

• age >70y

Related Conditions & MeSH terms

• Hcc

Intervention

Procedure:
• living donor liver transplantation
liver graft from a living donor

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Ain Shams University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	HCC recurrence	Recurrence of Hepatocellular carcinoma either intra-hepatic, extra-hepatic or both	3 years