Repeat Nasal Allergen Challenge

Hayfever Clinical Trial

Official title:

Assessment of Inflammatory Mediator and Cellular Changes Following Repeated Nasal Allergen Challenge in Subjects With Allergic Rhinitis Sensitive to Timothy Grass Pollen - a Validation Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00290368
• Other study ID #: CPJMR0052104
• Status: Completed
• Phase: Phase 2
• Start date: February 2006
• Est. completion date: May 2006

Study information

• Verified date: September 2023
• Source: Imperial College London
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This is a non-drug, biomarker study to assess the utility of the model of repeated nasal allergen challenges in subjects with atopic rhinitis as a method of inducing an increased response to inhaled allergen, which will more closely resemble the responses seen during the hayfever season.

Description:

This is a non-drug, biomarker study to assess the utility of the model of repeated nasal allergen challenges in subjects with atopic rhinitis as a method of inducing an increased response to inhaled allergen, which will more closely resemble the responses seen during the hayfever season.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 22
• Est. completion date: May 2006
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 40 Years

Eligibility

Inclusion Criteria:

1. Male and female subjects with a history of seasonal (intermittent) atopic rhinitis, aged 18-40 years.

2. Otherwise healthy with no health problems that may jeopardize the subjects participating in the study, absence of history of other significant allergies.

Exclusion Criteria:

1. Smokers (use of tobacco products in the previous 3 months).

2. Presence of any respiratory disease other than a history of mild stable asthma not requiring treatment and associated with normal lung function (FEV1 > 80% predicted at screening).

Related Conditions & MeSH terms

• Hayfever
• Rhinitis, Allergic, Seasonal

Intervention

Procedure:
• Skin Prick Test

• Nasal allergen challenge

• Nasal filter paper placement

• Nasal lavage

• Nasal scrape

• Nasal symptoms score

Locations

Country	Name	City	State
United Kingdom	National Heart & Lung Institute Clinical Studies Unit	London

Sponsors (2)

Lead Sponsor	Collaborator
Imperial College London	Novartis Pharmaceuticals

Country where clinical trial is conducted

United Kingdom,