Hay Fever Clinical Trial
Official title:
Evaluation of High Speed Laser Doppler Imaging Technology to Quantify Skin Prick Tests in Allergic Volunteers
Skin prick tests (SPT) are commonly used in daily allergological practice to assess skin
reactivity to allergens. Multiple factors can contribute to non-optimal results of
conventional wheal and flare measurement (CWFM) of SPT such as inaccurate measurements,
observer-dependency and absence of traceability.
This study aims to evaluate the quantification of SPT by a novel High Speed Laser Doppler
Imaging (HSL-DI) and to compare it with CWFM. First, SPT with birch and/or grass pollen
extracts as well as positive and negative controls will be performed in 20 volunteers (11
atopics, 9 non-atopics) to establish the characteristics (cut-off, optimal reading time and
allergen concentration) of HSL-DI analysis based on two parameters ("area" and "flow"
measurement). In a second step, fifty patients will be tested with birch and grass pollen
extracts at optimal allergen concentration and time window. Analysis of SPT by HSL-DI and
CWFM will be compared.
n/a
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
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