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NCT01102205 Clinical Trial

Evaluation of Oxidative Stress and Effect of Levothyroxine Treatment on Oxidative Stress in Hashimoto Disease

Hashimoto Disease Clinical Trial

Official title:
Evaluation of Oxidative Stress and Effect of Levothyroxine Treatment on Oxidative Stress in Hashimoto Disease

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT01102205
Other study ID # tastoshashi
Secondary ID
Status Completed
Phase N/A
First received April 9, 2010
Last updated June 11, 2013
Start date April 2010
Est. completion date October 2010

Study information
Verified date June 2013
Source Vakif Gureba Training and Research Hospital
Contact n/a
Is FDA regulated No
Health authority Turkey: Ministry of Health
Study type Observational

Clinical Trial Summary

Oxidative stress leads to or accompanies with numerous disease. Oxidative balance in subclinical hypothyroid or euthyroid state in Hashimoto disease are not known. Effect of levothyroxine therapy on oxidative balance are also not known in hashimoto disease.

Description:

oxidative stress markers will be measured initially(TAS,TOS,OSI,PARAOXONASE,ARYLESTERASA,PON1 PHENOTYPİNG,LİPİDPEROXİD).After 3 months therapy with levothyroxine measurements will be repeated except PON1 phenotyping.

Recruitment information / eligibility
Status Completed
Enrollment 130
Est. completion date October 2010
Est. primary completion date April 2010
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Both
Age group 18 Years to 95 Years
Eligibility Inclusion Criteria:

- age more than 18 years

Exclusion Criteria:

- inability to give a written consent

- other conditions and drug usage affect oxidative stress

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

Locations
Country Name City State
Turkey Vakif Gureba Training and Research Hospital Istanbul

Sponsors (1)
Lead Sponsor Collaborator
Vakif Gureba Training and Research Hospital

Country where clinical trial is conducted

Turkey, 

Outcome
Type Measure Description Time frame Safety issue
Primary Poxidative stress markers After levotren therapy No
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