Hand Surgery Clinical Trial
Official title:
Intravenous and Perineural Dexamethasone for Brachial Plexus Block in Hand Surgery
This study aims to evaluate the if the administration of dexamethasone both around the nerve and in the vein (perineural and intravenous (IV)) will prolong the duration of pain relief from ropivacaine when compared with ropivacaine local block alone or when administered along with IV dexamethasone in patients undergoing hand surgery.
Status | Recruiting |
Enrollment | 108 |
Est. completion date | June 30, 2024 |
Est. primary completion date | June 30, 2024 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 80 Years |
Eligibility | Inclusion Criteria: - Adult male and female patients age 18-80 - Undergoing distal radius ORIF (open reduction internal fixation) or CMC (Carpometacarpal) arthroplasty - ASA (American Society of Anesthesiologists) I, II,III - Patients who provide a signed written informed consent - Have a valid phone number and be able to speak, read, and write in English Exclusion Criteria: - Any documented cognitive or psychological disorders that, in the opinion of the principal investigator, can interfere with the patients' pain perception - Diabetes Mellitus - Vulnerable populations: pregnant females, prisoners, breast feeding - Contraindication to nerve block: local infections, bleeding disorders, shoulder deformity, allergy to local anesthetic or dexamethasone - Severe lung disease, known contralateral phrenic nerve injury - Previous history of chronic pain diseases requiring consistent analgesic therapy for at least 1 month prior to surgery - Presence of any medical condition that, in the opinion of the principal investigator, should exclude the patient from the study - BMI = 40 kg/m2 |
Country | Name | City | State |
---|---|---|---|
United States | The Ohio State University Wexner Medical Center | Columbus | Ohio |
Lead Sponsor | Collaborator |
---|---|
Ohio State University |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Duration of anesthetic blockade | • The duration of anesthetic blockade measured by the time from performing the perineural block to the first reported pain at the surgical site between groups | 48 hours | |
Secondary | Duration of motor block | • To compare the duration of motor block between groups (defined as the time between performance of the perineural block and full return of motor function in comparison to the contralateral limb) | 48 hours | |
Secondary | Patient satisfaction on a scale of 0-10 (0=not satisfied at all 10=very satisfied) of pain management | • To compare overall patient satisfaction of pain management between groups | 48 hours | |
Secondary | 48-hour postoperative units of oral morphine consumption | • To compare 48-hour postoperative units of oral morphine consumption between groups | 48 hours | |
Secondary | the incidence of nausea and/or vomiting within 48 hour of the block | • To compare the incidence of nausea and/or vomiting within 48 hour of the block | 48 hours | |
Secondary | • Rebound pain on a scale of 0-10 (0=no pain 10=worst possible pain), which is the worst level of pain experienced within the 2 hours after the block wore off | • Rebound pain (the worst pain in the 2 hours after the block wore off) | 48 hours |
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