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Hand Osteoarthritis clinical trials

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NCT ID: NCT06367283 Recruiting - Hand Osteoarthritis Clinical Trials

Metformin Treatment of Patients With Hand Osteoarthritis

METRO
Start date: June 2024
Phase: Phase 3
Study type: Interventional

To compare metformin (2 g daily), or maximum tolerated dose, for 16 weeks with placebo as a treatment of hand osteoarthritis symptoms.

NCT ID: NCT06329219 Recruiting - Hand Osteoarthritis Clinical Trials

Water-filtered Infrared-A Radiation in Patients With Hand Osteoarthritis

Start date: March 26, 2024
Phase: N/A
Study type: Interventional

The aim of this clinical trial is to evaluate the effects of water-filtered Infrared-A radiation on patients suffering from hand osteoarthritis. The main questions it aims to answer are: - Does water-filtered Infrared-A radiation reduce pain and improve the function of finger joints over time? - Are patients satisfied with the treatment results when compared to those who were on a wait-list?

NCT ID: NCT06281184 Not yet recruiting - Hand Osteoarthritis Clinical Trials

A Post-trial Follow-up of MERINO Participants to Evaluate Long-term Effects of Methotrexate Treatment in Adults With Erosive Hand OA.

MERINO:2
Start date: March 15, 2024
Phase:
Study type: Observational

In response to the high prevalence of synovitis in hand osteoarthritis (OA) and its association with pain, there's a compelling rationale for investigating the efficacy of MTX in managing inflammatory erosive hand OA. Recent guidelines highlight the need for large, well-designed trials to assess the effectiveness of MTX. A recent trial (METHODS study) showed promising pain reduction with MTX, but due to pandemic-related protocol changes, the duration of the study was limited to six months. The ongoing MERINO trial randomizes participants to MTX or placebo for one year. After completing the MERINO trial, several participants asked for MTX open label. In the subsequent MERINO:2 study, participants completing the trial will be invited to a structured follow-up after one year, including electronic questionnaires and hand radiographs, providing valuable long-term data on the effects of MTX in hand OA. Together, these trials aim to fill gaps in understanding the long-term impact of MTX in hand OA, particularly on structural progression.

NCT ID: NCT06264908 Not yet recruiting - Hand Osteoarthritis Clinical Trials

An Integrated Self Management Programme to Improve Outcomes in Patients With Hand Osteoarthritis

OASIS-H
Start date: April 2024
Phase: N/A
Study type: Interventional

The goal of this trial is to evaluate the efficacy of an integrated self-management programme in improving clinical outcomes in patients with hand osteoarthritis (OA). This is an open-labelled, randomized controlled trial with an objective to determine the efficacy of an integrated self-management programme versus routine clinical care for participants with symptomatic hand OA. Participants will be randomized into early intervention group and routine clinical care groups in a 1:1 ratio. Patients who randomized into early intervention group will receive 8 week integrated self-management programme delivered by occupational therapists and rheumatology nurse on hand OA management. Patients who randomized into routine clinical care group will receive usual clinical care for OA for 26 weeks and then receive an identical 8 weeks integrated self-management programme. The primary outcome is the improvement in pain at 26 weeks between the two groups.

NCT ID: NCT06254105 Recruiting - Hand Osteoarthritis Clinical Trials

Feasibility of a Cross-sectorial Management Program in Hand Osteoarthritis

HANDY
Start date: January 5, 2024
Phase: N/A
Study type: Interventional

To support the referral of people with Hand Osteoarthritis (HOA) to evidence-based occupational therapy addressing decreased ADL ability, a cross-sectorial management program for people with HOA, named HANDY, was developed. The HANDY program includes procedures for needs evaluation and referral, and a group-based occupational therapy program. The development was based on the United Kingdom's Medical Research Councils recommendations. A core element is involvement of stakeholders. Therefore, the research group has worked closely with GPs, OTs, people with HOA and specialist within rheumatology. Through a co-productional process the HANDY program was developed based on theories, research evidence, current best practice and the preferences of people with HOA. The aim of this study is to evaluate the feasibility of the HANDY

NCT ID: NCT06188221 Completed - Clinical trials for Carpal Tunnel Syndrome

Does Adding Lidocaine to Corticosteroid Injections Reduce Pain Intensity in Hand Surgery

Start date: February 1, 2020
Phase: N/A
Study type: Interventional

The purpose of this study was to determine whether adding Lidocaine to Corticosteroid injections reduce pain intensity in hand surgery.

NCT ID: NCT05568875 Completed - Hand Osteoarthritis Clinical Trials

Happy Hands - an E-self-management Intervention for People With Hand Osteoarthritis

HappyHands
Start date: November 8, 2022
Phase: N/A
Study type: Interventional

The main aim of this project is to assess the effect, cost-effectiveness and user experiences with using an e-self-management intervention in addition to treatment as usual compared to treatment as usual alone in patients with hand osteoarthritis. The study is an RCT comprising approx 400 participants with hand osteoarthritis recruited from primary and secondary healthcare in all four health regions in Norway.

NCT ID: NCT05499559 Recruiting - Hand Osteoarthritis Clinical Trials

Effects of 12-week Digital Treatment in Patients With Hand OA on Pain and Function

Start date: April 1, 2022
Phase:
Study type: Observational [Patient Registry]

The purpose of this study is to evaluate the effect of a 12 week digital treatment program for patients with hand osteoarthritis. The treatment consisted of exercises and educational sessions with respect to the disease, its natural course and recommended treatment strategies. Design: An observational longitudinal cohort study. The investigators will include participants who participated in the digital treatment of Joint Academy® for 3 months. Outcomes: Investigators will analyze pain with Numeric Rating Scale (NRS) 0-10 (best to worst), function with the Functional Index for Hand OsteoArthritis (FIHOA) and HRQL with EQ-5D-5L at baseline and at 3 months. Main outcome will be change in pain. The investigators will also analyze minimally clinical important changes (improved or not) and mean changes in EQ-5D-5L index score, pain and function.

NCT ID: NCT05267093 Recruiting - Hand Osteoarthritis Clinical Trials

Acupuncture vs Sham Acupuncture for Hand Osteoarthritis

Start date: April 26, 2022
Phase: N/A
Study type: Interventional

The investigators plan to conduct this multicentered, sham-controlled randomized clinical trial to evaluate the efficacy and safety of acupuncture for clinical symptomatic improvement of hand OA.

NCT ID: NCT05217979 Recruiting - Hand Osteoarthritis Clinical Trials

Pulsed Radiofrequency Therapy for Hand OsteoArthritis Pain

PROAP
Start date: April 4, 2022
Phase: N/A
Study type: Interventional

Different types of pain may be present in patients with hand osteoarthritis, including nociceptive pain and non-nociceptive pain. This makes adequate pain treatment difficult, and thus new treatment options are needed. To this end, this trial will evaluate the effect of transcutaneous pulsed radiofrequency for the treatment of hand osteoarthritis pain.