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Hand, Foot and Mouth Disease clinical trials

View clinical trials related to Hand, Foot and Mouth Disease.

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NCT ID: NCT06455007 Completed - Clinical trials for Propolis Antiviral Activity

Propolis as a Treatment Option for Hand Foot and Mouth Disease

Start date: January 1, 2019
Phase: Phase 2/Phase 3
Study type: Interventional

Hand foot and mouth disease (HFMD) is a frequently self-limited viral infectious disease in children with no specific antiviral treatment option. There has been an increasing interest in bee products in recent years, and propolis has come to the fore with its high therapeutic and protective effect. Although the inhibitory effect of propolis against enteroviruses (EVs) has been shown in studies, there is no clinical data regarding its use in the course of HFMD. The aim of this prospective multicenter randomized clinical study was to evaluate the effect of propolis use in children with HFMD. The patients were randomly assigned to have Anatolian propolis or no supplement - control group in addition to symptomatic therapy decided by the physician. The duration of the patients' complaints, the distribution of the lesions in the body, and the fever status were recorded on admission. Parents were asked to rate the severity of the child's restlessness, inappetence, and sleeplessness status on a scale of 0-10 on the initial, 2nd (at 48th hour), and 3rd (on 5-7 days) visits.

NCT ID: NCT06353477 Completed - Clinical trials for Hand, Foot, and Mouth Disease

Hand, Foot, and Mouth Disease: Could EPs®7630 be a Treatment Option

Start date: June 1, 2019
Phase: Phase 2/Phase 3
Study type: Interventional

This randomized controlled study aims to evaluate the effectiveness and safety of the pharmaceutical extract EPs® 7630 from P.sidoides in treating hand, foot, and mouth disease in children. The study will investigate the impact of EPs® 7630 on the severity of the disease over a specific period and its effects on hospitalization rates and potential complications. This research aims to contribute to the treatment of hand, foot, and mouth disease in children.

NCT ID: NCT06263439 Recruiting - Clinical trials for Hand, Foot and Mouth Disease

Surveillance of HFMD in Pediatric Outpatients

PMB
Start date: June 20, 2023
Phase:
Study type: Observational

The aims of this prospective multicentric study is to determine the types of enteroviruses (EVs) responsible for hand, foot and mouth disease (HFMD) or herpangina in children seen within an ambulatory setting : - to detect an EV-A71 epidemic or another type associated with atypical forms of the disease at an early stage - to describe and compare the epidemiological, demographic, clinical and virological characteristics of these infections between the different types of EV.

NCT ID: NCT06251219 Not yet recruiting - Clinical trials for Hand, Foot and Mouth Disease

Active Case Finding of Clinical Hand Foot Mouth Disease in Children Aged 6 Months Old to 18 Years Old in Indonesia

Start date: February 1, 2024
Phase:
Study type: Observational

An observational study of active case surveillance to identify the pathogens of clinically diagnosed HFMD cases aged 6 months to 18 years old recruited from puskesmas and hospitals in Indonesia.

NCT ID: NCT06209398 Active, not recruiting - Clinical trials for Hand, Foot and Mouth Disease

Immunogenicity of the Inactivated EV71 Vaccine Combined With Hepatitis B and Group A Meningococcal Vaccine

Start date: May 24, 2018
Phase: Phase 4
Study type: Interventional

The main purpose of this study is to evaluate the immunogenicity and safety of inactivated enterovirus type 71 vaccine combined with recombinant hepatitis B vaccine or Group a meningococcal polysaccharide vaccine.

NCT ID: NCT06146088 Recruiting - Clinical trials for Hand, Foot and Mouth Disease

Lot-to-lot Consistency Study of Three Commercial Batches of Enterovirus 71 Vaccine

Start date: November 25, 2023
Phase: Phase 4
Study type: Interventional

This study is a randomized, blinded study to evaluate the lot-to-lot consistency of immunogenicity, safety, and immune persistence of three consecutive manufacturing lots of EV71 vaccine, in 1500 children aged 6-35 months. The primary immunogenicity endpoint is the anti-EV71 neutralizing antibody geometric mean titer (GMT) 30 days after the final dose. The secondary immunogenicity endpoints are the geometric mean fold increases and seroconversion rates of anti-EV71 neutralizing antibodies 30 days after the final dose. The immune persistence endpoints are the seropositive rates as well as GMT of anti-EV71 neutralizing antibodies 12 and 24 months after the final dose. The safety endpoints are the number of adverse events/reactions within 30 minutes after each dose, the number of solicited adverse events/reactions within 7 days after each dose, the number of unsolicited adverse events/reactions within 30 days after each dose, and the number of serious adverse events (SAE) from the first dose to 6 months post the final dose.

NCT ID: NCT06063057 Recruiting - Clinical trials for Hand, Foot and Mouth Disease

Inactivated Bivalent Enterovirus Vaccine (Vero Cell) Phase I/II Clinical Trial

Start date: September 20, 2023
Phase: Phase 1/Phase 2
Study type: Interventional

The Phase I clinical trial is divided into two parts. The first part uses an open-label design, while the second part uses a randomized, double-blind, and controlled design. The goal of this clinical trial is to evaluate the tolerability and safety of a bivalent (EV71/CA16, Enterovirus 71/Coxsackievirus A16) inactivated enterovirus vaccine (Vero cell) developed by Sinovac. The vaccine will be administered to healthy adults, children aged 6 to 12 years, and children aged 6 to 71 months. The Phase II clinical trial will also use a randomized, double-blind, and controlled design to evaluate the safety and immunogenicity of the same bivalent inactivated enterovirus vaccine (Vero cell) developed by Sinovac. This trial will involve healthy children aged 6 to 71 months.

NCT ID: NCT05637229 Completed - Clinical trials for Hand, Foot and Mouth Disease

A Serosurvey Study of Hand, Foot, and Mouth Disease in Indonesia

Start date: November 28, 2022
Phase:
Study type: Observational [Patient Registry]

This study is a sero-survey study of infants aged 6 months to 71 months in Bandung City and West Bandung District. As initial data to find out how many children have been exposed to human enterovirus type 71 (HEV-71) which causes Hand, foot, and mouth disease (HFMD).

NCT ID: NCT05397587 Not yet recruiting - Clinical trials for Hand, Foot and Mouth Disease

An Immunity Persistence Study of Enterovirus 71 Inactivated Vaccine (Vero Cell)

Start date: July 30, 2022
Phase: Phase 4
Study type: Interventional

This is an open,observational and follow-up clinical trial based on the clinical trial of EV71 vaccine extended age group.The purpose of this study is to evaluate the immunity persistence of EV71 vaccine developed by Sinovac Biotech Co., Ltd in subjects aged 6 ~71 months after full immunization of two doses of vaccine.

NCT ID: NCT05166044 Recruiting - Clinical trials for Hand, Foot and Mouth Disease

Safety Observation of Enterovirus 71 Inactivated Vaccine (Vero Cell) Combined Immunization in Shanghai

Start date: January 4, 2022
Phase:
Study type: Observational

This study is an open clinical trial of the EV71 vaccine (Vero cell), Inactivated manufactured by Sinovac Research & Development Co.,Ltd.The purpose of this study is to evaluate the safety of EV71 vaccine (Vero cell), Inactivated co-administration with other vaccines