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Hand Deformities, Congenital clinical trials

View clinical trials related to Hand Deformities, Congenital.

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NCT ID: NCT01619644 Completed - Clinical trials for Rubinstein-Taybi Syndrome

Rubinstein-Taybi Syndrome: Functional Imaging and Therapeutic Trial

RUBIVAL
Start date: April 2012
Phase: Phase 2
Study type: Interventional

An exploratory phase 2 therapeutic trial in children from 6 to 21, RTS carriers, randomized to be treated either with sodium valproate with the usual pediatric dosage (30 mg/kg/j), or by placebo for one year. The investigator would like to include children because they could best profit from it due to their neuronal plasticity as CBP and EP300 take effect through neuronal and synaptic plasticity. The therapeutic effect of sodium valproate in RTS patients will be assessed thanks to a clinical approach (learning and memory neuropsychological evaluation, fine motor skills assessment by pointing), to a biological approach (histone acetylation functional tests), and to imaging (morphological and functional MRI).

NCT ID: NCT01416090 Completed - Clinical trials for Congenital Hand Deformities

Syndactyly Repair: Comparison of Skin Graft and No Skin Graft Techniques

Start date: July 2004
Phase:
Study type: Observational

Syndactyly is a relatively common congenital abnormality of the hand occurring approximately 1 out of 2500 live births (1). It can be simple, meaning only skin and soft tissues are shared, or complex, meaning the bone or nail parts are shared. In any case, it is a fact that there is not enough skin surrounding the two finger segment to be utilized to cover two separate fingers. This can also be proven by simple geometry. Therefore, it has always been taught to residents and explained to numerous patients' families that addition of skin graft is required for a proper syndactyly release. Without it, skin flaps would be too tight, causing some necrosis and significant scarring along the finger and particularly in the web space, causing an unsatisfactory functional and cosmetic result requiring revision.

NCT ID: NCT01409980 Completed - Clinical trials for Phalanx of Supernumerary Digit of Hand

Triphalangeal Thumbs in the Pediatric Population: Long Term Outcomes Following Surgical Intervention

Start date: July 2011
Phase: N/A
Study type: Observational

A triphalangeal thumb is a thumb with three phalanges. The thumb often appears long and fingerlike, and can sometimes be in the same plane as the other fingers. Anatomically, the extra phalanx can have different shapes. Several classification systems have been used, but the simplest and most often used is the Wood (1976) classification by the shape of the extra phalanx. If the extra phalanx is triangularly shaped it is classified as a type I. Type II has a rectangular shaped extra phalanx but it has not developed as a full phalanx. Type III is a full extra phalanx.