Clinical Trials Logo
  1. Home
  2. Halitosis
  3. NCT00748943

Clinical and Microbiological Effects of a Mouthwash Containing Chlorine Dioxide

Halitosis Clinical Trial

Official title:
The Clinical Effects of a Mouthwash Containing Chlorine Dioxide on Oral Malodor and Salivary Periodontal and Malodorous Bacteria Using for 7days

Clinical Trial Summary

Previous research has shown the oxidizing properties and microbiological efficacies of chlorine dioxide (ClO2). However, no clinical studies have investigated its microbiological efficacies on periodontal and malodorous bacteria. The aim of this study was to assess the inhibitory effects of a mouthwash containing ClO2 on morning oral malodor and on salivary periodontal and malodorous bacteria using for 7 days.

Clinical Trial Description

Background: Previous research has shown the oxidizing properties and microbiological efficacies of chlorine dioxide (ClO2). Its clinical efficacies on oral malodor have been evaluated and reported, however, no clinical studies have investigated its microbiological efficacies on periodontal and malodorous bacteria. The aim of this study was to assess the inhibitory effects of a mouthwash containing ClO2 on morning oral malodor and on salivary periodontal and malodorous bacteria using for 7 days.

Methods: A randomized, double blind, crossover, placebo-controlled clinical trial was conducted among 15 healthy male volunteers, who were divided into 2 groups. In the first test phase, the group 1 subjects (N = 8) were instructed to rinse with the experimental mouthwash containing ClO2 twice per day for 7 days, and those in group 2 (N = 7) to rinse with the control (placebo) mouthwash without ClO2. In the second test, phase after a one week washout period, each group had used the opposite mouthwash for 7 days. At baseline and after 7 days, oral malodor was evaluated with OM, and concentrations of hydrogen sulfide (H2S), methyl mercaptan (CH3SH) and dimethyl sulfide ((CH3)2S), the main VSCs of human oral malodor, were evaluated with GC. Clinical outcome variables included plaque and gingival indices, and the Winkel Tongue Coating Index(WTCI). The samples of saliva were microbiologically investigated.

Outcome variables were compared by t-test and Mann-Whitney test. ;

Study Design

Allocation: Randomized, Endpoint Classification: Safety Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Prevention

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00748943
Study type Interventional
Source Tokyo Medical and Dental University
Contact
Status Completed
Phase Phase 1
Start date March 2007
Completion date June 2007
View Details
See also
  Status Clinical Trial Phase
Completed NCT04279106 - Effect of Single Rinsing With Three Different Types of Mouthwash on VSC Levels in Morning Breath N/A
Completed NCT04914208 - Effect of Wearing Face Masks on Salivary Parameters and Halitosis N/A
Completed NCT05413382 - Effect of an Investigational Lozenge (Biofresh® 4plus) Versus Placebo Control on Oral Malodor (Intra-Oral Halitosis) N/A
Completed NCT05524948 - A Clinical Study to Examine the Effects of an Experimental Toothpaste Compared to a Regular Fluoride Toothpaste on Breath Odor in a Population With Gingivitis N/A
Completed NCT02689297 - Three Different Oral Hygiene Regimes on Three Volatile Sulfur Compounds Phase 4
Completed NCT02113137 - Oral Hygiene Procedures on Reduction of Oral Malodor Phase 4
Completed NCT01046812 - Halitosis Devised Questionnaire Evaluating a New Treatment N/A
Withdrawn NCT02665780 - Assessing the Effect of Periodontal Debridement, Tongue Cleaning and Mouth Rinsing for the Treatment of Oral Malodour N/A
Completed NCT01948349 - Impact of Bracket Design and Oral Hygiene Maintenance on Halitosis in the Orthodontic Patient N/A
Recruiting NCT02007993 - Photodynamic Therapy in Adolescents Halitosis N/A
Completed NCT01269957 - Halitosis and Mouth Breathing in Children N/A
Completed NCT04632004 - Questionnaire Regarding the Effect of Wearing Face Masks on Oral Health N/A
Completed NCT04998617 - Effects of Curcumin-containing Toothpaste on Dental Biofilm and Associated Oral Halitosis N/A
Not yet recruiting NCT00875927 - Effects of Breezy Candy on Halitosis Phase 1/Phase 2
Completed NCT01139073 - A New Portable Monitor for Measuring Odorous Compounds in Oral, Exhaled and Nasal Air N/A
Completed NCT03196648 - Randomized Trial of a Gum Health Formulation N/A
Recruiting NCT03346460 - Effect of Photodymamic Therapy With Urucum and LED in the Reduction of Halitosis Phase 2
Completed NCT03468595 - Clinical Evaluation of Some Local Antimicrobial Agents' Adjunctive Effects On Periodontal Parameters and Halitosis N/A
Completed NCT02628938 - Effect of Miswak and Miswak Extract on Oral Malodor Phase 2
Completed NCT02794766 - Inulin and S. Salivarius Reduce Halitosis Phase 2